Evidence map›Paper›PMID 29883274›Full record

ReviewAnnual review of vision science2018

Parallel Processing of Rod and Cone Signals: Retinal Function and Human Perception.

William N Grimes, Adree Songco-Aguas, Fred Rieke

Abstract readReview
In one paragraph

Review in Annual review of vision science, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.

0numbers the graph read from it
0cells of the map it votes in
37citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

37 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Review
  6. Observational
  7. Impact of Rod-Dominant Mesopic Conditions on Spatial Summation and Surround Suppression in Early Visual Cortex.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025
    Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Ancient origin of the rod bipolar cell pathway in the vertebrate retina.bioRxiv : the preprint server for biology · 2023
    Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Circadian Regulation of the Rod Contribution to Mesopic Vision in Mice.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

William N GrimesDepartment of Physiology and Biophysics, University of Washington, Seattle, Washington 98195, USA; email: rieke@u.washington.edu.
Adree Songco-AguasDepartment of Physiology and Biophysics, University of Washington, Seattle, Washington 98195, USA; email: rieke@u.washington.edu.
Fred RiekeDepartment of Physiology and Biophysics, University of Washington, Seattle, Washington 98195, USA; email: rieke@u.washington.edu.

Funding

Diversity Action Plan: UW GenOM ProjectR25HG007153 · NHGRI · UNIVERSITY OF WASHINGTON · PI EICHLER, EVAN · 2013 to 2020
$2.3M
Retinal interactions between rod and cone signalsR01EY028111 · NEI · UNIVERSITY OF WASHINGTON · PI RIEKE, FREDERICK M · 2017 to 2021
$1.9M
Training Program in Neural Computation and EngineeringR90DA033461 · NIDA · UNIVERSITY OF WASHINGTON · PI FAIRHALL, ADRIENNE L, SHEA-BROWN, ERIC TODD · 2011 to 2020
$1.9M
NEI NIH HHS R01 EY028111NHGRI NIH HHS R25 HG007153NIDA NIH HHS R90 DA033461
6 · The paper itself

Abstract

We know a good deal about the operation of the retina when either rod or cone photoreceptors provide the dominant input (i.e., under very dim or very bright conditions). However, we know much less about how the retina operates when rods and cones are coactive (i.e., under intermediate lighting conditions, such as dusk). Such mesopic conditions span 20-30% of the light levels over which vision operates and encompass many situations in which vision is essential (e.g., driving at night). These lighting conditions are challenging because rod and cone signals differ substantially: Rod responses are nearing saturation, while cone responses are weak and noisy. A rich history of perceptual studies guides our investigation of how the retina operates under mesopic conditions and in doing so provides a powerful opportunity to link general issues about parallel processing in neural circuits with computation and perception. We review some of the successes and challenges in understanding the retinal basis of perceptual rod-cone interactions.

Indexed as

HumansMesopic VisionRetinaRetinal Cone Photoreceptor CellsRetinal Rod Photoreceptor CellsRod-Cone InteractionVisual Perceptioncircuitconeparallel processingperceptionretinarod

Identifiers

PMID29883274
PMCPMC6153147

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.