ArticleInternational forum of allergy & rhinology2018
Mucus T helper 2 biomarkers predict chronic rhinosinusitis disease severity and prior surgical intervention.
Article in International forum of allergy & rhinology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 49 citations in OpenAlex.
- Use of Machine Learning and 71-Plex Immune Mediator Analysis to Identify Nasal Mucus Biomarkers Associated With Olfactory Loss in Patients with CRSwNP.American journal of rhinology & allergy · 2026Article
- Establishing the PMThe Journal of allergy and clinical immunology · 2026Article
- Long-Term Particulate Matter Exposure May Increase Risk of Chronic Rhinosinusitis WIth Nasal Polyposis: Results From an Exposure-Matched Study.International forum of allergy & rhinology · 2025Article
- Effects of inflammatory endotypes on disease trajectory in chronic rhinosinusitis with nasal polyps.The Journal of allergy and clinical immunology · 2025Article
- Biodiversity of the Bacterial and Fungal Microbiome and Associated Inflammatory Cytokine Profile in Chronic Rhinosinusitis.International forum of allergy & rhinology · 2025Article
- ARIA-Italy multidisciplinary consensus on nasal polyposis and biological treatments: Update 2025.The World Allergy Organization journal · 2025Review
- Type 2 biomarkers in olfactory cleft mucus correlate with SNOT-22 in chronic rhinosinusitis independent of nasal polyp status.International forum of allergy & rhinology · 2025Observational
- Particulate matter exposure is associated with increased inflammatory cytokines and eosinophils in chronic rhinosinusitis.Allergy · 2024Article
- Utilization of RNA sequencing to investigate olfactory dysfunction in chronic rhinosinusitis without nasal polyps: A pilot study.World journal of otorhinolaryngology - head and neck surgery · 2024Article
- Polyps' Extension and Recurrence in Different Endotypes of Chronic Rhinosinusitis: A Series of 449 Consecutive Patients.Journal of clinical medicine · 2024Article
- Inflammatory characteristics of central compartment atopic disease.International forum of allergy & rhinology · 2023Article
- The Diagnostic and Prognostic Role of Biomarkers in Chronic Rhinosinusitis.Diagnostics (Basel, Switzerland) · 2023Review
- Identification of Inflammatory Endotypes by Clinical Characteristics and Nasal Secretion Biomarkers in Chronic Rhinosinusitis with Nasal Polyps.International archives of allergy and immunology · 2023Article
- Utilization of Nasal Mucus to Investigate the Pathophysiology of Chronic Rhinosinusitis.American journal of rhinology & allergy · 2022Review
- [Research progress of biomarkers in nasal secretions in endotypes diagnosis and clinical application of chronic rhinosinusitis].Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology head and neck surgery · 2022Review
- CRS-PRO and SNOT-22 correlations with type 2 inflammatory mediators in chronic rhinosinusitis.International forum of allergy & rhinology · 2022Article
- Different Roles of Dendritic Cells for Chronic Rhinosinusitis Treatment According to Phenotype.International journal of molecular sciences · 2022Review
- Current insight into treatment of chronic rhinosinusitis: Phenotypes, endotypes, and implications for targeted therapeutics.The Journal of allergy and clinical immunology · 2022Review
- Inflammatory heterogeneity in aspirin-exacerbated respiratory disease.The Journal of allergy and clinical immunology · 2021Article
- Elevated mucus interleukin-17A levels are associated with increased prior sinus surgery for chronic rhinosinusitis.International forum of allergy & rhinology · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
backgroundChronic rhinosinusitis (CRS) is a diverse clinical syndrome with a heterogeneous pathophysiology. Early attempts to identify CRS endotypes and biomarkers have largely relied on analysis of surgically obtained tissue, thus limiting their practical utility. This study examined the ability of mucus T helper 2 (Th2) biomarkers to predict CRS disease severity and clinical characteristics.
methodsCRS (n = 90) and healthy control subjects (n = 17) were prospectively enrolled prior to surgical intervention and mucus levels of interleukin (IL)-4, IL-5, and IL-13 were determined using a multiplex cytometric bead assay. Data for relevant cytokines was then scaled, normalized, and later combined to develop standardized metrics indicative of Th2-associated inflammation. Th2-high and Th2-low subgroups were consequently identified and validated against factors associated with disease severity and clinical outcomes.
resultsMucus levels of IL-5 and IL-13 were elevated in CRS subjects compared to controls, while no significant difference was noted for IL-4. IL-5 and IL-13 high CRS were associated with worse objective measures of disease severity and greater rates of revision surgery. Similar relationships were noted for both cytokines when CRS with nasal polyps (CRSwNP) patients were analyzed separately. Th2-high CRS and Th2-low CRS were then categorized using a scaled IL-5/IL-13 metric. Th2-high CRS was characterized by an increased number of subjects with nasal polyps and comorbid asthma, and worse symptom and computed tomography (CT) scores.
conclusionThe Th2-associated cytokines, IL-5 and IL-13, are detectable in sinonasal mucus and their levels can be used to define Th2-high and Th2-low CRS. Identification of Th2-high and Th2-low endotypes using mucus-based biomarkers could facilitate stratification of CRS subgroups and guide personalized therapies.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.