Evidence map›Paper›PMID 29883052›Full record

ArticleJournal of the International AIDS Society2018

Optimal timing of HIV home-based counselling and testing rounds in Western Kenya.

Jack J Olney, Jeffrey W Eaton, Paula Braitstein, Joseph W Hogan, Timothy B Hallett

Abstract read
In one paragraph

Article in Journal of the International AIDS Society, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Article
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  6. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors.

Jack J OlneyCentre for Health Economics & Policy Innovation, Imperial College Business School, London, United Kingdom.ORCID 0000-0002-7257-7840
Jeffrey W EatonDepartment of Infectious Disease Epidemiology, Imperial College London, London, United Kingdom.ORCID 0000-0001-7728-728X
Paula BraitsteinDalla Lana School of Public Health, University of Toronto, Toronto, Canada.
Joseph W HoganDepartment of Biostatistics and Center for Statistical Sciences, Brown University School of Public Health, Providence, RI, USA.
Timothy B HallettDepartment of Infectious Disease Epidemiology, Imperial College London, London, United Kingdom.

Funding

East Africa International Epidemiology Database to evaluate AIDS (IeDEA) Regional ConsortiumU01AI069911 · NIAID · INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS · PI AGGREY SEMWENDERO SEMEERE, Kara Kay Wools-Kaloustian · 2006 to 2026
$57.7M
Translational ScienceP30AI042853 · NIAID · MIRIAM HOSPITAL · PI CURT G BECKWITH · 1998 to 2026
$51.7M
Science/Technical CoreP2CHD041020 · NICHD · BROWN UNIVERSITY · PI Margot Jackson · 2016 to 2026
$7.6M
Optimizing HIV Treatment Monitoring under Resource ConstraintsR01AI108441 · NIAID · BROWN UNIVERSITY · PI HOGAN, JOSEPH W, KANTOR, RAMI · 2015 to 2019
$3.5M
Medical Research Council MR/R015600/1NIAID NIH HHS P30 AI042853NIAID NIH HHS R01 AI108441NIAID NIH HHS U01 AI069911NICHD NIH HHS P2C HD041020
6 · The paper itself

Abstract

introductionWeaknesses in care programmes providing anti-retroviral therapy (ART) persist and are often instigated by late HIV diagnosis and poor linkage to care. We investigated the potential for a home-based counselling and testing (HBCT) campaign to be improved through the optimal timing and enhancement of testing rounds to generate greater health outcomes at minimum cost.

methodsUsing a mathematical model of HIV care calibrated to longitudinal data from The Academic Model Providing Access To Healthcare (AMPATH) in Kenya, we simulated HBCT campaigns between 2016 and 2036, assessing the impact and total cost of care for each, for a further 20 years.

resultsWe find that simulating five equally spaced rounds averts 1.53 million disability-adjusted life-years (DALYs) at a cost of $1617 million. By altering the timing of HBCT rounds, a four-round campaign can produce greater impact for lower cost. With "front-loaded" rounds, the cost per DALY averted is reduced by 12% as fewer rounds are required ($937 vs. $1060). Furthermore, improvements to HBCT coverage and linkage to care avert over two million DALYs at a cost per DALY averted of $621 (41% less than the reference scenario).

conclusionsCountries implementing HBCT can reduce costs by optimally timing rounds and generate greater health outcomes through improving linkage, coverage, and retention. Tailoring HBCT campaigns to individual settings can enhance patient outcomes for minimal cost.

Indexed as

CounselingAdultFemaleHIV InfectionsHumansKenyaQuality-Adjusted Life YearsTime Factorsantiretroviral therapycare cascadeHIVHIV testinghome-based counselling & testingmathematical modeltreatment cascade

Identifiers

PMID29883052
PMCPMC5993164

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.