Evidence map›Paper›PMID 29882971›Full record

SynthesisPaediatric and perinatal epidemiology2018

Breast milk transmission of flaviviruses in the context of Zika virus: A systematic review.

Taylor Z Mann, Lisa B Haddad, Tonya R Williams, Susan L Hills, Jennifer S Read, Deborah L Dee, Eric J Dziuban, Janice Pérez-Padilla, Denise J Jamieson, Margaret A Honein and 1 more

Open access · bronzeAbstract readSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Paediatric and perinatal epidemiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed, 2 pooled it
8.7field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 2 syntheses or guidelines pooled it, 61 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Review
  4. Review
  5. Article
  6. Article
  7. Viruses and Human Milk: Transmission or Protection?Advances in nutrition (Bethesda, Md.) · 2023
    Review
  8. Article
  9. Article
  10. Review
  11. Revisiting Koch's postulate to determine the plausibility of viral transmission by human milk.Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology · 2021
    Article
  12. Article
  13. Article
  14. Review
  15. Review
  16. Article
  17. Review
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  19. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 3 countries.

Taylor Z MannDivision of Congenital and Developmental Disorders, Centers for Disease Control and Prevention, Atlanta, GA, USA.ORCID 0000-0002-9648-2520
Lisa B HaddadDivision of Reproductive Health, Centers for Disease Control and Prevention, Atlanta, GA, USA.
Tonya R WilliamsDivision of Human Development and Disability, Centers for Disease Control and Prevention, Atlanta, GA, USA.
Susan L HillsDivision of Vector-Borne Diseases, Centers for Disease Control and Prevention, Fort Collins, CO, USA.
Jennifer S ReadDivision of Vector-Borne Diseases, Centers for Disease Control and Prevention, Fort Collins, CO, USA.
Deborah L DeeDivision of Reproductive Health, Centers for Disease Control and Prevention, Atlanta, GA, USA.
Eric J DziubanDivision of Human Development and Disability, Centers for Disease Control and Prevention, Atlanta, GA, USA.
Janice Pérez-PadillaDivision of Vector-Borne Diseases, Centers for Disease Control and Prevention, Fort Collins, CO, USA.
Denise J JamiesonDivision of Reproductive Health, Centers for Disease Control and Prevention, Atlanta, GA, USA.
Margaret A HoneinDivision of Congenital and Developmental Disorders, Centers for Disease Control and Prevention, Atlanta, GA, USA.
Carrie K Shapiro-MendozaDivision of Reproductive Health, Centers for Disease Control and Prevention, Atlanta, GA, USA.
Centers for Disease Control and Prevention · USOak Ridge Associated Universities · US

Funding

Impact of progestin contraception on risk of HIV acquisition and transmissionK23HD078153 · NICHD · EMORY UNIVERSITY · PI HADDAD, LISA BLAKE · 2014 to 2018
$704k
Intramural CDC HHS CC999999NICHD NIH HHS K23 HD078153
6 · The paper itself

Abstract

backgroundSince the Zika virus epidemic in the Americas began in 2015, Zika virus transmission has occurred throughout the Americas. However, limited information exists regarding possible risks of transmission of Zika virus and other flaviviruses through breast feeding and human milk. We conducted a systematic review of the evidence regarding flaviviruses detection in and transmission through milk, specifically regarding Zika virus, Japanese encephalitis virus, tick-borne encephalitis virus, Powassan virus, West Nile virus, dengue virus, and yellow fever virus.

methodsMedline, Embase, Global Health, CINAHL, Cochrane Library, Scopus, Popline, Virtual Health Library, and WorldCat were searched through June 2017. Two authors independently screened potential studies for inclusion and extracted data. Human and nonhuman (animal) studies describing: 1) confirmed or suspected cases of mother-to-child transmission through milk; or 2) the presence of flavivirus genomic material in milk.

resultsSeventeen studies were included, four animal models and thirteen observational studies. Dengue virus, West Nile virus, and Zika virus viral ribonucleic acid was detected in human milk, including infectious Zika virus and dengue virus viral particles. Human breast-feeding transmission was confirmed for only yellow fever virus. There was evidence of milk-related transmission of dengue virus, Powassan virus, and West Nile virus in animal studies.

conclusionsBecause the health advantages of breast feeding are considered greater than the potential risk of transmission, the World Health Organization recommends that mothers with possible or confirmed Zika virus infection or exposure continue to breast feed. This review did not identify any data that might alter this recommendation.

Indexed as

HumansInfant, NewbornInfant, Newborn, DiseasesInfectious Disease Transmission, VerticalMilk, HumanPractice Guidelines as TopicRisk FactorsZika VirusZika Virus Infectionbreast feeding transmissionbreast milkflavivirusZika virus

Identifiers

PMID29882971
PMCPMC6103797
OpenAlexW2805269256

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.