ArticleNutrients2018
Quality of Life in Patients with Gluten Neuropathy: A Case-Controlled Study.
Article in Nutrients, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 3 of them syntheses that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
15 citing papers in PubMed, 3 syntheses or guidelines pooled it, 29 citations in OpenAlex.
- Quality of Life in Painful Peripheral Neuropathies: A Systematic Review.Pain research & management · 2019Pooled it
- Pooled it
- Pooled it
- What's New in Neuropathy?Cureus · 2023Review
- Review
- Acrodystrophic axonal polyneuropathy with celiac disease: a case report.Journal of medical case reports · 2021Article
- Review
- Gluten neuropathy: electrophysiological progression and HLA associations.Journal of neurology · 2021Article
- Celiac Disease: Extraintestinal Manifestations and Associated Conditions.Journal of clinical gastroenterology · 2020Review
- Pain in Chronic Inflammatory Demyelinating Polyradiculoneuropathy: A Systematic Review and Meta-Analysis.Pain and therapy · 2019Review
- Treatment of Neurological Manifestations of Gluten Sensitivity and Coeliac Disease.Current treatment options in neurology · 2019Review
- Gluten-Induced Extra-Intestinal Manifestations in Potential Celiac Disease-Celiac Trait.Nutrients · 2019Review
- Psychological Aspects and Quality of Life in Chronic Pain.Pain research & management · 2019Article
- Gluten neuropathy: prevalence of neuropathic pain and the role of gluten-free diet.Journal of neurology · 2018Article
- Gluten-Associated Neurological Disorders: A Cases Series.Case reports in gastroenterologyArticle
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundGluten neuropathy (GN) is defined as an otherwise idiopathic peripheral neuropathy in the presence of serological evidence of gluten sensitivity (positive native gliadin antibodies and/or transglutaminase or endomysium antibodies). We aimed to compare the quality of life (QoL) of GN patients with that of control subjects and to investigate the effects of a gluten-free diet (GFD) on the QoL.
methodsAll consecutive patients with GN attending a specialist neuropathy clinic were invited to participate. The Overall Neuropathy Limitations Scale (ONLS) was used to assess the severity of the neuropathy. The 36-Item Short Form Survey (SF-36) questionnaire was used to measure participants’ QoL. A strict GFD was defined as effectively being able to eliminate all circulating gluten sensitivity-related antibodies.
resultsFifty-three patients with GN and 53 age- and gender-matched controls were recruited. Compared to controls, GN patients showed significantly worse scores in the physical functioning, role limitations due to physical health, energy/fatigue, and general health subdomains of the SF-36. After adjusting for age, gender, and disease severity, being on a strict GFD correlated with better SF-36 scores in the pain domain of the SF-36 (beta 0.317,
conclusionIn GN patients, physical dysfunctioning is the major determinant of poor QoL compared to controls. Routine checking of the elimination of gluten sensitivity-related antibodies that results from a strict GFD should be encouraged, as such elimination ameliorates the overall pain and health scores, indicating a better QoL.
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