Evidence map›Paper›PMID 29882843›Full record

Trial reportNutrients2018

A Randomized, Double-Blinded, Placebo-Controlled Study to Compare the Safety and Efficacy of Low Dose Enhanced Wild Blueberry Powder and Wild Blueberry Extract (ThinkBlue™) in Maintenance of Episodic and Working Memory in Older Adults.

Adrian R Whyte, Nancy Cheng, Emilie Fromentin, Claire M Williams

3 registry-linked trialsAbstract readComparative StudyRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Nutrients, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 70 papers, 9 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
70citing papers in PubMed, 9 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02446314 nacompletednot on this map

A Randomized, Double-blind, Placebo-controlled Study Investigating the Effects of a Wild Blueberry Powder and a Wild Blueberry Extract on Cognition in Older Adults

TypeinterventionalSponsorUniversity of ReadingRan2015 to 2017Enrolled122ConditionsCognitive DeclineArmsPlacebo, Wild Blueberry Powder - 450mg, Wild Blueberry Powder - 900 mg, Wild Blueberry extract 100mg
NCT04049162 nacompletednot on this mapstarted 2019, after this paper: background citation

Effects of Blueberry Consumption on Vascular Function, Physical Activity, and Cognition in Sedentary Older Adults

TypeinterventionalSponsorDuke UniversityRan2019 to 2022Enrolled84ConditionsSedentary Lifestyle, Blood Pressure, Arterial Stiffness, Overweight and ObesityArmsBlueberry Plus Exercise (BB-EX), Blueberry Placebo Plus Exercise (P-EX)
NCT04986956 nacompletednot on this mapstarted 2022, after this paper: background citation

Longitudinal Study to Assess the Effects of Whole Coffee Cherry Extract (WCCE)

TypeinterventionalSponsorAuburn UniversityRan2022 to 2024Enrolled323ConditionsEffect of DrugArmsWhole coffee cherry extract, Placebo
3 · Its place in the literature

Who cites it

70 citing papers in PubMed, 9 syntheses or guidelines pooled it.

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10 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Adrian R WhyteSchool of Psychology and Clinical Language Sciences, University of Reading, Reading RG6 6AL, UK. a.r.whyte@reading.ac.uk.
Nancy ChengSchool of Psychology and Clinical Language Sciences, University of Reading, Reading RG6 6AL, UK. nancy.cheng@pgr.reading.ac.uk.
Emilie FromentinNaturex Inc., 375 Huyler Street, South Hackensack, NJ 07606, USA. e.fromentin@naturex-dbs.com.
Claire M WilliamsSchool of Psychology and Clinical Language Sciences, University of Reading, Reading RG6 6AL, UK. claire.williams@reading.ac.uk.ORCID 0000-0003-4452-671X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Previous research has shown beneficial effects of polyphenol-rich diets in ameliorating cognitive decline in aging adults. Here, using a randomized, double blinded, placebo-controlled chronic intervention, we investigated the effect of two proprietary blueberry formulations on cognitive performance in older adults; a whole wild blueberry powder at 500 mg (WBP500) and 1000 mg (WBP1000) and a purified extract at 100 mg (WBE111). One hundred and twenty-two older adults (65⁻80 years) were randomly allocated to a 6-month, daily regimen of either placebo or one of the three interventions. Participants were tested at baseline, 3, and 6 months on a battery of cognitive tasks targeting episodic memory, working memory and executive function, alongside mood and cardiovascular health parameters. Linear mixed model analysis found intervention to be a significant predictor of delayed word recognition on the Reys Auditory Verbal Learning Task (RAVLT), with simple contrast analysis revealing significantly better performance following WBE111 at 3 months. Similarly, performance on the Corsi Block task was predicted by treatment, with simple contrast analysis revealing a trend for better performance at 3 months following WBE111. Treatment also significantly predicted systolic blood pressure (SBP) with simple contrast analysis revealing lower SBP following intervention with WBE111 in comparison to placebo. These results indicate 3 months intervention with WBE111 can facilitate better episodic memory performance in an elderly population and reduce cardiovascular risk factors over 6 months.

Indexed as

Cognitive AgingMemory, EpisodicAffectAgedAged, 80 and overAge FactorsBlueberry PlantsCognitionDouble-Blind MethodEnglandExecutive FunctionFemaleFruitGeriatric AssessmentHumansMaleNootropic AgentsPlant ExtractsPowdersanthocyaninblood pressurecognitionepisodic memoryflavonoidolder adultswild blueberry

Identifiers

PMID29882843
PMCPMC6024810

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.