ArticleNanomaterials (Basel, Switzerland)2018
Dose- and Time-Dependent Cytotoxicity of Layered Black Phosphorus in Fibroblastic Cells.
Article in Nanomaterials (Basel, Switzerland), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 70 citations in OpenAlex.
- Black Phosphorus Nanosheets Penetrate the Blood-Testis Barrier and Induce Reproductive Toxicity in Male Mice.Environment & health (Washington, D.C.) · 2026Article
- Article
- Engineered bio-functional material-based nerve guide conduits for optic nerve regeneration: a view from the cellular perspective, challenges and the future outlook.Regenerative biomaterials · 2025Review
- Emerging 2D Nanomaterials-Integrated Hydrogels: Advancements in Designing Theragenerative Materials for Bone Regeneration and Disease Therapy.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Review
- Cytotoxicity Induced by Black Phosphorus Nanosheets in Vascular Endothelial Cells via Oxidative Stress and Apoptosis Activation.Journal of functional biomaterials · 2023Article
- Ternary MXene-loaded PLCL/collagen nanofibrous scaffolds that promote spontaneous osteogenic differentiation.Nano convergence · 2022Article
- Unique Interaction between Layered Black Phosphorus and Nitrogen Dioxide.Nanomaterials (Basel, Switzerland) · 2022Article
- Strategies to Improve Photodynamic Therapy Efficacy of Metal-Free Semiconducting Conjugated Polymers.International journal of nanomedicine · 2022Review
- Development of Two-Dimensional Nanomaterials Based Electrochemical Biosensors on Enhancing the Analysis of Food Toxicants.International journal of molecular sciences · 2021Review
- Black Phosphorus as Multifaceted Advanced Material Nanoplatforms for Potential Biomedical Applications.Nanomaterials (Basel, Switzerland) · 2020Review
- Two-Dimensional Theranostic Nanomaterials in Cancer Treatment: State of the Art and Perspectives.Cancers · 2020Review
- TEM Studies on Antibacterial Mechanisms of Black Phosphorous Nanosheets.International journal of nanomedicine · 2020Article
- Nonlinear Optical Response of Graphene Oxide Langmuir-Blodgett Film as Saturable Absorbers.Nanomaterials (Basel, Switzerland) · 2019Article
- Optical Nonlinearity of ZrS₂ and Applications in Fiber Laser.Nanomaterials (Basel, Switzerland) · 2019Article
- Impact of bisphosphonates on the proliferation and gene expression of human fibroblasts.International journal of medical sciences · 2019Article
- Application of black phosphorus nanodots to live cell imaging.Biomaterials research · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Black phosphorus (BP) is a monolayer/multilayer two-dimensional (2D) nanomaterial, which has recently emerged as one of the most attractive 2D nanomaterials due to its fascinating physicochemical and optoelectronical properties. Layered BP may have promising applications in biomedical fields, such as drug delivery, photodynamic/photothermal therapy and bioimaging, although its intrinsic toxicity has not been fully elucidated yet. In the present study, the cytotoxicological effects of layered BP on both cell metabolic activity and membrane integrity were investigated. Layered BPs were prepared using a modified ultrasonication-assisted solution method, and their physicochemical properties were characterized. The dose- and time-dependent cytotoxicity of layered BP was assessed against L-929 fibroblasts. Our findings indicate that the cytotoxicity of BPs is proportionally dependent on their concentration and exposure time, which is affected by the oxidative stress-mediated enzyme activity reduction and membrane disruption. On the other hand, layered BPs did not exhibit significant cytotoxicity at concentrations lower than 4 μg/mL. Therefore, it is suggested that layered BPs can be effectively utilized as therapeutic delivery carriers and imaging agents.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.