Evidence map›Paper›PMID 29882792›Full record

ArticleViruses2018

The

Jennifer Patterson-West, Tamara D James, Llorenç Fernández-Coll, James R Iben, Kyung Moon, Leslie Knipling, Michael Cashel, Deborah M Hinton

Abstract read
In one paragraph

Article in Viruses, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Virus-Host Interaction GetsInternational journal of molecular sciences · 2021
    Article
  10. Article
  11. A widespread toxin-antitoxin system exploiting growth control via alarmone signaling.Proceedings of the National Academy of Sciences of the United States of America · 2020
    Article
  12. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Jennifer Patterson-WestGene Expression and Regulation Section, Laboratory of Cell and Molecular Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20814, USA. jennifer.west@nih.gov.
Tamara D JamesGene Expression and Regulation Section, Laboratory of Cell and Molecular Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20814, USA. tamara.james@ihs.gov.
Llorenç Fernández-CollSection on Microbial Regulation, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20814, USA. llorenc.fernandezcoll@nih.gov.
James R IbenMolecular Genomics Core, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20814, USA. james.iben@nih.gov.
Kyung MoonGene Expression and Regulation Section, Laboratory of Cell and Molecular Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20814, USA. kyung.moon@nih.gov.
Leslie KniplingGene Expression and Regulation Section, Laboratory of Cell and Molecular Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20814, USA. lesliek@mail.nih.gov.
Michael CashelSection on Microbial Regulation, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20814, USA. cashelm@mail.nih.gov.
Deborah M HintonGene Expression and Regulation Section, Laboratory of Cell and Molecular Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20814, USA. dhinton@helix.nih.gov.

Funding

Bacteriophage T4 Gene ExpressionZIADK057802 · NIDDK · NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES · PI HINTON, DEBORAH M · 2009 to 2025
$5.2M
Novel tool for linking drugs to phenotypes - I-Corps SupplementR43GM113546 · NIGMS · GENECENTRIX, INC. · PI FELSOVALYI, KLARA O · 2015 to 2016
$808k
NIGMS NIH HHS R43 GM113546
6 · The paper itself

Abstract

Bacteriophage T4 relies on host RNA polymerase to transcribe three promoter classes: early (Pe, requires no viral factors), middle (Pm, requires early proteins MotA and AsiA), and late (Pl, requires middle proteins gp55, gp33, and gp45). Using primer extension, RNA-seq, RT-qPCR, single bursts, and a semi-automated method to document plaque size, we investigated how deletion of DksA or ppGpp, two

Indexed as

Transcription, GeneticBacteriophage T4Escherichia coliEscherichia coli ProteinsGene DeletionGene Expression ProfilingGene Expression Regulation, ViralGuanosine TetraphosphateReal-Time Polymerase Chain ReactionSequence Analysis, RNAViral Plaque AssayVirus ReplicationdksA protein, E coliEscherichia coli ProteinsGuanosine Tetraphosphatebacteriophage T4DksAMotARNA-seqtranscriptome analysis

Identifiers

PMID29882792
PMCPMC6024815

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.