Evidence map›Paper›PMID 29882782›Full record

ReviewInternational journal of molecular sciences2018

Balneotherapy, Immune System, and Stress Response: A Hormetic Strategy?

Isabel Gálvez, Silvia Torres-Piles, Eduardo Ortega-Rincón

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in International journal of molecular sciences, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 78 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
78citing papers in PubMed, 5 pooled it
24.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

78 citing papers in PubMed, 5 syntheses or guidelines pooled it, 178 citations in OpenAlex.

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  5. Efficacy of aquatic therapy for neck pain: a systematic review.International journal of biometeorology · 2020
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18 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Isabel GálvezResearch Group in Immunophysiology, Department of Physiology, Faculty of Sciences, University of Extremadura, Avda. Elvas s/n, 06071 Badajoz, Spain. igalvez@unex.es.ORCID 0000-0002-4294-4507
Silvia Torres-PilesResearch Group in Immunophysiology, Department of Medical-Surgical Therapy, Faculty of Medicine, University of Extremadura, Avda. Elvas s/n, 06071 Badajoz, Spain. storres@unex.es.
Eduardo Ortega-RincónResearch Group in Immunophysiology, Department of Physiology, Faculty of Sciences, University of Extremadura, Avda. Elvas s/n, 06071 Badajoz, Spain. orincon@unex.es.ORCID 0000-0002-7007-7615
Universidad de Extremadura · ES

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Balneotherapy is a clinically effective complementary approach in the treatment of low-grade inflammation- and stress-related pathologies. The biological mechanisms by which immersion in mineral-medicinal water and the application of mud alleviate symptoms of several pathologies are still not completely understood, but it is known that neuroendocrine and immunological responses—including both humoral and cell-mediated immunity—to balneotherapy are involved in these mechanisms of effectiveness; leading to anti-inflammatory, analgesic, antioxidant, chondroprotective, and anabolic effects together with neuroendocrine-immune regulation in different conditions. Hormesis can play a critical role in all these biological effects and mechanisms of effectiveness. The hormetic effects of balneotherapy can be related to non-specific factors such as heat—which induces the heat shock response, and therefore the synthesis and release of heat shock proteins—and also to specific biochemical components such as hydrogen sulfide (H₂S) in sulfurous water and radon in radioactive water. Results from several investigations suggest that the beneficial effects of balneotherapy and hydrotherapy are consistent with the concept of hormesis, and thus support a role for hormesis in hydrothermal treatments.

Indexed as

ImmunityStress, PhysiologicalAnimalsBalneologyHormesisHumansHydrotherapyTreatment Outcomeheat shock proteinshormesishydrotherapyimmune responseinflammationmud therapyoxidative stresspainrheumatic diseasesspa therapy

Identifiers

PMID29882782
PMCPMC6032246
OpenAlexW2806482569

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.