Evidence map›Paper›PMID 29882777›Full record

ArticleMolecules (Basel, Switzerland)2018

Discovering Structural Motifs in miRNA Precursors from the

Joanna Miskiewicz, Marta Szachniuk

Abstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
  4. How bioinformatics resources work with G4 RNAs.Briefings in bioinformatics · 2021
    Review
  5. Article
  6. Article
  7. Molecular Computing and Bioinformatics.Molecules (Basel, Switzerland) · 2019
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Joanna MiskiewiczInstitute of Computing Science, Poznan University of Technology, 60-965 Poznan, Poland. joanna.miskiewicz@cs.put.poznan.pl.
Marta SzachniukInstitute of Computing Science, Poznan University of Technology, 60-965 Poznan, Poland. marta.szachniuk@cs.put.poznan.pl.ORCID 0000-0002-8724-7908

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A small non-coding molecule of microRNA (19⁻24 nt) controls almost every biological process, including cellular and physiological, of various organisms’ lives. The amount of microRNA (miRNA) produced within an organism is highly correlated to the organism’s key processes, and determines whether the system works properly or not. A crucial factor in plant biogenesis of miRNA is the Dicer Like 1 (DCL1) enzyme. Its responsibility is to perform the cleavages in the miRNA maturation process. Despite everything we already know about the last phase of plant miRNA creation, recognition of miRNA by DCL1 in pre-miRNA structures of plants remains an enigma. Herein, we present a bioinformatic procedure we have followed to discover structure patterns that could guide DCL1 to perform a cleavage in front of or behind an miRNA:miRNA* duplex. The patterns in the closest vicinity of microRNA are searched, within pre-miRNA sequences, as well as secondary and tertiary structures. The dataset consists of structures of plant pre-miRNA from the

Indexed as

Nucleic Acid ConformationMicroRNAsRNA, PlantRNA PrecursorsViridiplantaeMicroRNAsRNA, PlantRNA PrecursorsDCL1miRNA biogenesisstructural patterns

Identifiers

PMID29882777
PMCPMC6100135

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.