Evidence map›Paper›PMID 29882770›Full record

ArticleInternational journal of molecular sciences2018

Radioprotective Effects of Dermatan Sulfate in a Preclinical Model of Oral Mucositis-Targeting Inflammation, Hypoxia and Junction Proteins without Stimulating Proliferation.

Sylvia Gruber, Marlene Arnold, Nilsu Cini, Victoria Gernedl, Sabine Hetzendorfer, Lisa-Marie Kowald, Peter Kuess, Julia Mayer, Susanne Morava, Stephanie Pfaffinger and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.4field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
  2. Article
  3. Modulation of radiation-induced oral mucositis (mouse) by dermatan sulfate: effects on differentiation processes.Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al] · 2020
    Article
  4. Galactosaminoglycans: Medical Applications and Drawbacks.Molecules (Basel, Switzerland) · 2019
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 2 countries.

Sylvia GruberChristian Doppler Laboratory for Medical Radiation Research for Radiation Oncology, Medical University/AKH Vienna, 1090 Vienna, Austria. sylvia.gruber@meduniwien.ac.at.
Marlene ArnoldDepartment of Radiation Oncology, Applied and Translational Radiobiology, Medical University Vienna, 1090 Vienna, Austria. marlene.arnold@meduniwien.ac.at.
Nilsu CiniDepartment of Radiation Oncology, Kartal Dr. Lutfi Kırdar Training and Research Hospital, Health Science University, 34722 Istanbul, Turkey. nilsu.cini@gmail.com.
Victoria GernedlDepartment of Radiation Oncology, Applied and Translational Radiobiology, Medical University Vienna, 1090 Vienna, Austria. victoria.gernedl@meduniwien.ac.at.
Sabine HetzendorferDepartment of Radiation Oncology, Applied and Translational Radiobiology, Medical University Vienna, 1090 Vienna, Austria. sabine.hetzendorfer@meduniwien.ac.at.
Lisa-Marie KowaldDepartment of Radiation Oncology, Applied and Translational Radiobiology, Medical University Vienna, 1090 Vienna, Austria. lisa_kowald@hotmail.com.
Peter KuessChristian Doppler Laboratory for Medical Radiation Research for Radiation Oncology, Medical University/AKH Vienna, 1090 Vienna, Austria. peter.kuess@meduniwien.ac.at.
Julia MayerDepartment of Radiation Oncology, Applied and Translational Radiobiology, Medical University Vienna, 1090 Vienna, Austria. julia_mayer92@gmx.at.
Susanne MoravaDepartment of Radiation Oncology, Applied and Translational Radiobiology, Medical University Vienna, 1090 Vienna, Austria. susanne.morava@meduniwien.ac.at.
Stephanie PfaffingerDepartment of Radiation Oncology, Applied and Translational Radiobiology, Medical University Vienna, 1090 Vienna, Austria. stephanie.pfafffinger@meduniwien.ac.at.
Andreas RohorzkaDepartment of Radiation Oncology, Applied and Translational Radiobiology, Medical University Vienna, 1090 Vienna, Austria. andreasrohorzka@gmx.at.
Wolfgang DörrDepartment of Radiation Oncology, Applied and Translational Radiobiology, Medical University Vienna, 1090 Vienna, Austria. wolfgang.doerr@meduniwien.ac.at.
Medical University of Vienna · ATChristian Doppler Laboratory for Thermoelectricity · ATDr Lütfi Kırdar Kartal Eğitim ve Araştırma Hastanesi · TR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Oral mucositis is the most frequently occurring early side effect of head-and-neck cancer radiotherapy. Systemic dermatan sulfate (DS) treatment revealed a significant radioprotective potential in a preclinical model of oral mucositis. This study was initiated to elucidate the mechanistic effects of DS in the same model. Irradiation comprised daily fractionated irradiation (5 × 3 Gy/week) over two weeks, either alone (IR) or in combination with daily dermatan sulfate treatment of 4 mg/kg (IR + DS). Groups of mice (

Indexed as

AnimalsCell ProliferationDermatan SulfateDisease Models, AnimalHead and Neck NeoplasmsHypoxiaInflammationIntercellular JunctionsMiceRadiation-Protective AgentsRadiotherapyStomatitisDermatan SulfateRadiation-Protective Agentscellular junctionsdermatan sulfatefractionationhypoxiainflammationmouse modeloral mucositis

Identifiers

PMID29882770
PMCPMC6032103
OpenAlexW2806655048

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.