ArticleAmerican journal of physiology. Heart and circulatory physiology2018
Multiscale structure-function relationships in right ventricular failure due to pressure overload.
Article in American journal of physiology. Heart and circulatory physiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 18 citations in OpenAlex.
- Targeting Mechanics to Restore Right Ventricular Function: A New Frontier in Pulmonary Arterial Hypertension Therapy.Function (Oxford, England) · 2025Article
- Right ventricular diastolic adaptation to pressure overload in different rat strains.Physiological reports · 2024Article
- An in-silico analysis of experimental designs to study ventricular function: A focus on the right ventricle.PLoS computational biology · 2022Article
- Sex differences in right ventricular adaptation to pressure overload in a rat model.Journal of applied physiology (Bethesda, Md. : 1985) · 2022Article
- Gpx3 and Egr1 Are Involved in Regulating the Differentiation Fate of Cardiac Fibroblasts under Pressure Overload.Oxidative medicine and cellular longevity · 2022Article
- Comparative analysis of right ventricular metabolic reprogramming in pre-clinical rat models of severe pulmonary hypertension-induced right ventricular failure.Frontiers in cardiovascular medicine · 2022Article
- Current Understanding of the Right Ventricle Structure and Function in Pulmonary Arterial Hypertension.Frontiers in physiology · 2021Review
- Estrogen receptor-α prevents right ventricular diastolic dysfunction and fibrosis in female rats.American journal of physiology. Heart and circulatory physiology · 2020Article
- Hemodynamic assessment of diastolic function for experimental models.American journal of physiology. Heart and circulatory physiology · 2020Review
- Bimodal right ventricular dysfunction after postnatal hyperoxia exposure: implications for the preterm heart.American journal of physiology. Heart and circulatory physiology · 2019Article
- Protection against pressure overload-induced right heart failure by uncoupling protein 2 silencing.Cardiovascular research · 2019Article
- Article
- Pressure-based estimation of right ventricular ejection fraction: Validation as a clinically relevant target for drug development in a rodent model of pulmonary hypertension.Journal of pharmacological and toxicological methodsArticle
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
Right ventricular (RV) failure (RVF) is the major cause of death in pulmonary hypertension. Recent studies have characterized changes in RV structure in RVF, including hypertrophy, fibrosis, and abnormalities in mitochondria. Few, if any, studies have explored the relationships between these multiscale structural changes and functional changes in RVF. Pulmonary artery banding (PAB) was used to induce RVF due to pressure overload in male rats. Eight weeks postsurgery, terminal invasive measurements demonstrated RVF with decreased ejection fraction (70 ± 10 vs. 45 ± 15%, sham vs. PAB, P < 0.005) and cardiac output (126 ± 40 vs. 67 ± 32 ml/min, sham vs. PAB, P < 0.05). At the organ level, RV hypertrophy was directly correlated with increased contractility, which was insufficient to maintain ventricular-vascular coupling. At the tissue level, there was a 90% increase in fibrosis that had a direct correlation with diastolic dysfunction measured by reduced chamber compliance ( r
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