ArticleThe American journal of tropical medicine and hygiene2018
Pathway to Deployment of Gene Drive Mosquitoes as a Potential Biocontrol Tool for Elimination of Malaria in Sub-Saharan Africa: Recommendations of a Scientific Working Group
Article in The American journal of tropical medicine and hygiene, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 114 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
114 citing papers in PubMed, 1 synthesis or guideline pooled it.
- A typology of community and stakeholder engagement based on documented examples in the field of novel vector control.PLoS neglected tropical diseases · 2019Pooled it
- Compound effector genes suppress malaria parasite infections in gene-drive population modification strains of the African malaria mosquitoes, Anopheles gambiae and Anopheles coluzzii.G3 (Bethesda, Md.) · 2026Article
- Knowledge, perspectives, and risk perceptions on gene drive and genetically modified mosquitoes for malaria control among African stakeholders: a scoping review protocol.Systematic reviews · 2026Article
- Mapping Gene Drive Dynamics onto Mendelian Models.bioRxiv : the preprint server for biology · 2026Article
- Exploratory conversations with biodiversity-oriented civil society groups on the potential applications of gene drive-modified mosquitoes for malaria control in Tanzania.Transgenic research · 2026Article
- Reinventing malaria control: hierarchical intervention strategies for African settings based on the microbiota-barrier-innate immunity axis.Frontiers in immunology · 2026Review
- Spatial close-kin mark-recapture methods to estimate dispersal parameters and barrier strength for mosquitoes.PLoS computational biology · 2025Article
- Is Gene Drive Research Losing Traction?The American journal of tropical medicine and hygiene · 2025Article
- Gene drive: communication, hype, and the publics.Journal of medical entomology · 2025Article
- Integrating malaria vaccine and CRISPR/Cas9 gene drive: a comprehensive strategy for accelerated malaria eradication.Malaria journal · 2025Review
- A model-informed target product profile for population modification gene drives for malaria control.PLOS global public health · 2025Article
- Procedural legitimacy: co-developing a community agreement model for genetic approaches research to malaria control in Africa.Malaria journal · 2024Article
- Post-release monitoring pathway for the deployment of gene drive-modified mosquitoes for malaria control in Africa.Malaria journal · 2024Article
- Emerging public health strategies in malaria control: innovations and implications.Annals of medicine and surgery (2012) · 2024Review
- Patterns of Gene Flow inEvolutionary applications · 2024Article
- Current status of the sterile insect technique for the suppression of mosquito populations on a global scale.Infectious diseases of poverty · 2024Review
- Practical Application of a Relationship-Based Model to Engagement for Gene-Drive Vector Control Programs.The American journal of tropical medicine and hygiene · 2024Article
- Eliminating malaria vectors with precision-guided sterile males.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Arthropod promoters for genetic control of disease vectors.Trends in parasitology · 2024Review
- Assessing CRISPR/Cas9 potential in SDG3 attainment: malaria elimination-regulatory and community engagement landscape.Malaria journal · 2024Review
54 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
15 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Gene drive technology offers the promise for a high-impact, cost-effective, and durable method to control malaria transmission that would make a significant contribution to elimination. Gene drive systems, such as those based on clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR associated protein, have the potential to spread beneficial traits through interbreeding populations of malaria mosquitoes. However, the characteristics of this technology have raised concerns that necessitate careful consideration of the product development pathway. A multidisciplinary working group considered the implications of low-threshold gene drive systems on the development pathway described in the World Health Organization
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.