Evidence map›Paper›PMID 29882206›Full record

ReviewJournal of bioenergetics and biomembranes2018

Purinergic receptors and neglected tropical diseases: why ignore purinergic signaling in the search for new molecular targets?

P A F Pacheco, L P Dantas, L G B Ferreira, Robson Xavier Faria

Abstract readReview
PubMed Publisher
In one paragraph

Review in Journal of bioenergetics and biomembranes, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.2field-weighted citation impact, top 52% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 6 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

P A F PachecoDepartment of Chemistry, Chemistry Institute, Fluminense Federal University, Niterói, Brazil.
L P DantasLaboratory of Molecular Virology, Biology Institute, Fluminense Federal University, Niterói, Brazil.
L G B FerreiraLaboratory of Inflammation, Oswaldo Cruz Institute, FIOCRUZ, Rio de Janeiro, Brazil.
Robson Xavier FariaLaboratory of Toxoplasmosis and other Protozoans, FIOCRUZ, Oswaldo Cruz Institute, Rio de Janeiro, Brazil. robson.xavier@gmail.com.ORCID 0000-0001-8218-834X
Fundação Oswaldo Cruz · BRUniversidade Federal Fluminense · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Purinergic receptors are widespread in the human organism and are involved in several physiological functions like neurotransmission, nociception, platelet aggregation, etc. In the immune system, they may regulate the expression and release of pro-inflammatory factors as well as the activation and death of several cell types. It is already described the participation of some purinergic receptors in the inflammation and pathological processes, such as a few neglected tropical diseases (NTDs) which affect more than 1 billion people in the world. Although the high social influence those diseases represent endemic countries, most of them do not have an efficient, safe or affordable drug treatment. In that way, this review aims to discuss the current literature involving purinergic receptor and immune response to NTDs pathogens, which may contribute in the search for new therapeutic possibilities.

Indexed as

AnimalsHumansImmunityInflammationMolecular Targeted TherapyNeglected DiseasesReceptors, PurinergicSignal TransductionTropical MedicineReceptors, PurinergicATPNeglected diseasesPurinergic receptorsTherapy

Identifiers

PMID29882206
OpenAlexW2806667783

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.