ArticleClinical rheumatology2018
Basic calcium phosphate and pyrophosphate crystals in early and late osteoarthritis: relationship with clinical indices and inflammation.
Article in Clinical rheumatology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 38 citations in OpenAlex.
- The association between articular calcium crystal deposition and knee osteoarthritis, joint pain and inflammation: a cross-sectional study.Skeletal radiology · 2025Trial
- Redox-immune modulating gadolinium vanadate based nanozymes for osteoarthritis therapy.Materials today. Bio · 2026Article
- Investigating the association between calcium-phosphorus balance and osteoarthritis: Evidence from NHANES 2007-2016.Medicine · 2025Observational
- Imaging-based measures of synovitis in knee osteoarthritis: A scoping review and narrative synthesis.Osteoarthritis and cartilage open · 2025Review
- Is It Time to Revisit the Role of Interleukin-1 Inhibitors in Osteoarthritis?Diabetes, metabolic syndrome and obesity : targets and therapy · 2025Review
- Interplay of calcium pyrophosphate crystals, oxidative stress, and clinical features on knee osteoarthritis severity.Clinical rheumatology · 2025Article
- Synovial Fluid from Patients with Osteoarthritis Shows Different Inflammatory Features Depending on the Presence of Calcium Pyrophosphate Crystals.International journal of molecular sciences · 2023Article
- The 2023 ACR/EULAR classification criteria for calcium pyrophosphate deposition disease.Annals of the rheumatic diseases · 2023Article
- The 2023 ACR/EULAR Classification Criteria for Calcium Pyrophosphate Deposition Disease.Arthritis & rheumatology (Hoboken, N.J.) · 2023Article
- Article
- Relationship Amongst Vitamin K Status, Vitamin K Antagonist Use and Osteoarthritis: A Review.Drugs & aging · 2022Review
- Usefulness of ultrasound in the diagnosis of crystal deposition diseases.European journal of rheumatology · 2022Article
- Disease-modifying therapeutic strategies in osteoarthritis: current status and future directions.Experimental & molecular medicine · 2021Review
- Cartilage-derived biomarkers in osteoarthritis.The Indian journal of medical research · 2021Article
- Amentadione from the AlgaMarine drugs · 2020Article
- CD11b Signaling Prevents Chondrocyte Mineralization and Attenuates the Severity of Osteoarthritis.Frontiers in cell and developmental biology · 2020Article
- Urate and osteoarthritis: Evidence for a reciprocal relationship.Joint bone spine · 2019Review
- IL-1 in osteoarthritis: time for a critical review of the literature.F1000Research · 2019Review
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
The current study aimed to investigate the association of calcium pyrophosphate (CPP) and basic calcium phosphate (BCP) crystals in synovial fluid (SF) of patients with osteoarthritis (OA) with disease severity, clinical symptoms, and synovial inflammation. One-hundred-and-ten patients with knee OA completed the Western Ontario and McMaster Universities Arthritis Index (WOMAC) self-assessment questionnaire, the Lequesne algofunctional index survey, and the visual analogic scale forms; they also underwent power Doppler ultrasonography (PDUS) to assess synovial inflammation. Scanning electron microscopy (SEM) was used to detect SF crystals. SEM analyses uncovered CPP crystals in 26 patients (23.6%), BCP crystals in 24 patients (21.8%), and both types of crystals in 7 patients (6.3%). Categorizing patients according to SF crystal type, a strong association between BCP crystal presence, and higher WOMAC and Lequesne index scores has been uncovered. Classifying our patients according the severity Kellgre-Lawrence score, we found that the prevalence of CPP alone (27.8%) or in combination with BCP (11.1%) was higher in the late stage group with respect to the early one (CPP 21.6% and CPP + BCP 4.1%, respectively). The prevalence of BCP crystals alone was, instead, higher in the early (23%) with respect to the late group (19.4%). No association between the presence of crystals and the radiographic scores has been observed. Considering the growing evidence supporting a role of low-grade inflammation in OA pathogenesis, the results of this study suggest a role for calcium crystals in the development of the disease.
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Registered trials
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