Evidence map›Paper›PMID 29882152›Full record

ArticleOphthalmology and therapy2018

Potential Effect of Cyclophosphamide on Bleb Survival in Five Patients with Multiple Sclerosis Who Underwent Glaucoma Surgery.

Andrea Giudiceandrea, Maria Emanuela Toro, Andrea Scupola, Aldo Caporossi, Viviana Nociti, Massimiliano Mirabella, Tommaso Salgarello

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Ophthalmology and therapy, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.2field-weighted citation impact, top 45% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Andrea GiudiceandreaOphthalmology Division - Department of Head and Neck Surgery of Catholic University of "Sacro Cuore", Fondazione Policlinico Universitario "A. Gemelli", Rome, Italy.
Maria Emanuela ToroOphthalmology Division - Department of Head and Neck Surgery of Catholic University of "Sacro Cuore", Fondazione Policlinico Universitario "A. Gemelli", Rome, Italy. emanuelatoro@tiscali.it.ORCID http://orcid.org/0000-0002-9304-1906
Andrea ScupolaOphthalmology Division - Department of Head and Neck Surgery of Catholic University of "Sacro Cuore", Fondazione Policlinico Universitario "A. Gemelli", Rome, Italy.
Aldo CaporossiOphthalmology Division - Department of Head and Neck Surgery of Catholic University of "Sacro Cuore", Fondazione Policlinico Universitario "A. Gemelli", Rome, Italy.
Viviana NocitiCatholic University of "Sacro Cuore", Fondazione Policlinico Universitario "A. Gemelli", Rome, Italy.
Massimiliano MirabellaCatholic University of "Sacro Cuore", Fondazione Policlinico Universitario "A. Gemelli", Rome, Italy.
Tommaso SalgarelloOphthalmology Division - Department of Head and Neck Surgery of Catholic University of "Sacro Cuore", Fondazione Policlinico Universitario "A. Gemelli", Rome, Italy.
Don Carlo Gnocchi Foundation · ITUniversità Cattolica del Sacro Cuore · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionThe purpose of this case series was to report the potential role of cyclophosphamide (CY) on bleb survival and to evaluate the safety of the trabeculectomy procedure under immunosuppressant systemic therapy. CASE SERIES: Five eyes of five patients with unresponsive to intraocular pressure (IOP) lowering medication, progressive glaucoma, underwent mytomicin C (MMC) augmented phaco-trabeculectomy, performed by the same surgeon, A.G., during the period from May 2015 to January 2016. All patients were treated with low doses of systemic CY at the time of surgery, to control their relapsing progressive multiple sclerosis (MS) form.

resultsDuring a mean follow-up period of 20.6 ± 8.1 months, for cases of "complete success" (when the IOP was < 15 mmHg without glaucoma therapy) were observed, while one case was classified as a "qualified success" since the IOP was ≤ 15 mmHg with β-blocker drops. There were no bleb infections, nor bleb-related complications.

conclusionThis study reports the safety of performing the filtration surgical procedure under immunosuppressant systemic therapy and provides a possible explication of CY anti-fibrotic mechanism and its possible role on bleb survival. Our findings may suggest new perspectives of study in this field.

Indexed as

Anti-fibroticBleb survivalCyclophosphamideImmunosuppressantsMultiple sclerosisTrabeculectomy

Identifiers

PMID29882152
PMCPMC6258581
OpenAlexW2806223184

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.