ArticleJournal of computer-aided molecular design2018
Touching proteins with virtual bare hands : Visualizing protein-drug complexes and their dynamics in self-made virtual reality using gaming hardware.
Article in Journal of computer-aided molecular design, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
10 citing papers in PubMed, 24 citations in OpenAlex.
- Beyond the flat screen: evaluating virtual reality as a complementary tool for molecular docking in drug discovery.Journal of computer-aided molecular design · 2026Review
- SparStVR - exploring sparse 3D histology data in virtual reality.Communications engineering · 2026Article
- Perspectives of 360-Degree Cinematic Virtual Reality: Interview Study Among Health Care Professionals.JMIR medical education · 2022Article
- Augmented Reality, a Review of a Way to Represent and Manipulate 3D Chemical Structures.Journal of chemical information and modeling · 2022Review
- A Brave New World: Virtual Reality and Augmented Reality in Systems Biology.Frontiers in bioinformatics · 2022Article
- ProteinVR: Web-based molecular visualization in virtual reality.PLoS computational biology · 2020Article
- Building blocks for commodity augmented reality-based molecular visualization and modeling in web browsers.PeerJ. Computer science · 2020Article
- An immersive journey to the molecular structure of SARS-CoV-2: Virtual reality in COVID-19.Computational and structural biotechnology journal · 2020Review
- Peppy: A virtual reality environment for exploring the principles of polypeptide structure.Protein science : a publication of the Protein Society · 2020Article
- Virtual Reality in Pharmacy: Opportunities for Clinical, Research, and Educational Applications.P & T : a peer-reviewed journal for formulary management · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
The ability to precisely visualize the atomic geometry of the interactions between a drug and its protein target in structural models is critical in predicting the correct modifications in previously identified inhibitors to create more effective next generation drugs. It is currently common practice among medicinal chemists while attempting the above to access the information contained in three-dimensional structures by using two-dimensional projections, which can preclude disclosure of useful features. A more accessible and intuitive visualization of the three-dimensional configuration of the atomic geometry in the models can be achieved through the implementation of immersive virtual reality (VR). While bespoke commercial VR suites are available, in this work, we present a freely available software pipeline for visualising protein structures through VR. New consumer hardware, such as the HTC VIVE and the OCULUS RIFT utilized in this study, are available at reasonable prices. As an instructive example, we have combined VR visualization with fast algorithms for simulating intramolecular motions of protein flexibility, in an effort to further improve structure-led drug design by exposing molecular interactions that might be hidden in the less informative static models. This is a paradigmatic test case scenario for many similar applications in computer-aided molecular studies and design.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.