Evidence map›Paper›PMID 29882035›Full record

ArticleImmunologic research2018

Immunomodulatory function of Treg-derived exosomes is impaired in patients with relapsing-remitting multiple sclerosis.

Maryam Azimi, Mojdeh Ghabaee, Abdorreza Naser Moghadasi, Farshid Noorbakhsh, Maryam Izad

Abstract read
PubMed Publisher
In one paragraph

Article in Immunologic research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.

0numbers the graph read from it
0cells of the map it votes in
43citing papers in PubMed
4.2field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

43 citing papers in PubMed, 53 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. Article
  5. Review
  6. Article
  7. Review
  8. Harnessing extracellular vesicle-mediated crosstalk between T cells and cancer cells for therapeutic applications.Journal of controlled release : official journal of the Controlled Release Society · 2025
    Review
  9. Review
  10. Article
  11. Review
  12. Review
  13. Article
  14. Review
  15. Review
  16. Review
  17. Roles of Regulatory T Cell-Derived Extracellular Vesicles in Human Diseases.International journal of molecular sciences · 2022
    Review
  18. Review
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Maryam AzimiDepartment of Immunology, School of Medicine, Tehran University of Medical Sciences, Poorsina St., 16 Azar St., Enghelab Ave., Tehran, Iran.
Mojdeh GhabaeeDepartment of Neurology, Iranian Center of Neurological Research, Imam Khomeini Hospital, Tehran University of Medical Sciences, Tehran, Iran.
Abdorreza Naser MoghadasiMS Research Center, Neuroscience Institute, Tehran University of Medical Sciences, Tehran, Iran.
Farshid NoorbakhshDepartment of Immunology, School of Medicine, Tehran University of Medical Sciences, Poorsina St., 16 Azar St., Enghelab Ave., Tehran, Iran.
Maryam IzadDepartment of Immunology, School of Medicine, Tehran University of Medical Sciences, Poorsina St., 16 Azar St., Enghelab Ave., Tehran, Iran. izadm@sina.tums.ac.ir.ORCID 0000-0002-7816-4051
Tehran University of Medical Sciences · IRImam Khomeini Hospital · IRSina Hospital · IR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Multiple sclerosis (MS) is an autoimmune disease which is characterized by neuroaxonal degeneration in the central nervous system. Impaired function of regulatory T cells (Tregs) is believed to be an underlying pathogenic mechanism in MS. Tregs is able to release exosomes, which contain a considerable amount of protein and RNA. Exosomes are capable of transporting their content to other cells where the released content exerts biological functions. Here, we investigated whether Tregs exosomes of RRMS patients or healthy controls might regulate the proliferation or survival of T lymphocytes. Regulatory T cells derived from MS patients or healthy controls were cultured for 3 days and exosomes were purified from supernatants. Treg-derived exosomes were co-cultured with conventional T cells (Tconv). The percentages of Tconv proliferation and apoptosis were measured. Our findings showed that the percentage of proliferation suppression induced by exosomes in patients compared to healthy controls was 8.04 ± 1.17 and 12.5 ± 1.22, respectively, p value = 0.035. Moreover, the rate of Tconv apoptosis induced by exosome of MS patient was less than healthy controls (0.68 ± 0.12 vs. 1.29 ± 0.13; p value = 0.015). Overall, Treg-derived exosomes from MS patients and healthy controls suppressed the proliferation and induced apoptosis in Tconv. However, the effect of MS-derived exosomes was significantly less than healthy controls. Our results point to an alternative Treg inhibitory mechanism which might be important in immunopathogenesis of MS. Although, the cause of the exosomal defect in MS patients is unclear, manipulation of patients' Treg-derived exosomes to restore their suppressive activity might be considered as a potential therapeutic approach. Graphical abstract ᅟ.

Indexed as

AdultApoptosisCell ProliferationCells, CulturedCell SurvivalCoculture TechniquesExosomesFemaleHumansImmunomodulationInterleukin-2 Receptor alpha SubunitMaleMultiple Sclerosis, Relapsing-RemittingT-Lymphocytes, RegulatoryT-Lymphocyte SubsetsInterleukin-2 Receptor alpha SubunitExosomeMultiple sclerosisRegulatory T cellT lymphocytesTreg-derived exosomes

Identifiers

PMID29882035
OpenAlexW2806694029

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.