ArticleBrain structure & function2018
Differential associations of combined vs. isolated cannabis and nicotine on brain resting state networks.
Article in Brain structure & function, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 36 citations in OpenAlex.
- Is resting-state functional connectivity altered in regular cannabis users? A systematic review of the literature.Psychopharmacology · 2022Pooled it
- Chronic cannabis use is associated with alterations in resting-state cerebellar-cortical connectivity.Psychopharmacology · 2026Article
- Multidimensional components of impulsivity during early adolescence: Relationships with brain networks and future substance-use in the Adolescent Brian and Cognitive Development (ABCD) study.bioRxiv : the preprint server for biology · 2025Article
- Interrelated involvement of the endocannabinoid/endovanilloid (TRPV1) systems and epigenetic processes in anxiety- and working memory impairment-related behavioural effects of nicotine as a stressor.Addiction biology · 2024Article
- Pathogenesis of E-Cigarette Vaping Product Use-Associated Lung Injury (EVALI).Comprehensive Physiology · 2023Article
- Association of tobacco and marijuana use with symptoms of depression and anxiety among adolescents and young adults in Texas.Tobacco prevention & cessation · 2022Article
- Abnormal white matter within brain structural networks is associated with high-impulse behaviour in codeine-containing cough syrup dependent users.European archives of psychiatry and clinical neuroscience · 2021Article
- Sex and dependence related neuroanatomical differences in regular cannabis users: findings from the ENIGMA Addiction Working Group.Translational psychiatry · 2021Article
- Unraveling the role of cigarette use in neural cannabis cue reactivity in heavy cannabis users.Addiction biology · 2021Article
- Associations of cannabis use disorder with cognition, brain structure, and brain function in African Americans.Human brain mapping · 2021Article
- Resting state functional connectivity in the default mode network: Relationships between cannabis use, gender, and cognition in adolescents and young adults.NeuroImage. Clinical · 2021Article
- Co-occurring tobacco and cannabis use in adolescents: Dissociable relationships with mediofrontal electrocortical activity during reward feedback processing.NeuroImage. Clinical · 2021Article
- The effects of nicotine and cannabis co-use during adolescence and young adulthood on white matter cerebral blood flow estimates.Psychopharmacology · 2020Article
- Evaluating the resource allocation index as a potential fMRI-based biomarker for substance use disorder.Drug and alcohol dependence · 2020Article
- Dynamic functional connectivity between nucleus accumbens and the central executive network relates to chronic cannabis use.Human brain mapping · 2020Article
- Adolescent Cannabinoid and Nicotine Exposure Differentially Alters Adult Nicotine Self-Administration in Males and Females.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2020Article
- Sex-related differences in subjective, but not neural, cue-elicited craving response in heavy cannabis users.Drug and alcohol dependence · 2020Article
- Interaction of Cannabis Use and Aging: From Molecule to Mind.Journal of dual diagnosisReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 3 institutions in 1 country.
Funding
Abstract
Concomitant cannabis and nicotine use is more prevalent than cannabis use alone; however, to date, most of the literature has focused on associations of isolated cannabis and nicotine use limiting the generalizability of existing research. To determine differential associations of concomitant use of cannabis and nicotine, isolated cannabis use and isolated nicotine use on brain network connectivity, we examined systems-level neural functioning via independent components analysis (ICA) on resting state networks (RSNs) in cannabis users (CAN, n = 53), nicotine users (NIC, n = 28), concomitant nicotine and cannabis users (NIC + CAN, n = 26), and non-users (CTRL, n = 30). Our results indicated that the CTRL group and NIC + CAN users had the greatest functional connectivity relative to CAN users and NIC users in 12 RSNs: anterior default mode network (DMN), posterior DMN, left frontal parietal network, lingual gyrus, salience network, right frontal parietal network, higher visual network, insular cortex, cuneus/precuneus, posterior cingulate gyrus/middle temporal gyrus, dorsal attention network, and basal ganglia network. Post hoc tests showed no significant differences between (1) CTRL and NIC + CAN and (2) NIC and CAN users. These findings of differential associations of isolated vs. combined nicotine and cannabis use demonstrate an interaction between cannabis and nicotine use on RSNs. These unique and combined mechanisms through which cannabis and nicotine influence cortical network functional connectivity are important to consider when evaluating the neurobiological pathways associated with cannabis and nicotine use.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.