ArticleIntensive care medicine2018
Management and outcomes of acute respiratory distress syndrome patients with and without comorbid conditions.
Article in Intensive care medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
32 citing papers in PubMed, 2 syntheses or guidelines pooled it, 108 citations in OpenAlex.
- The potential association between common comorbidities and severity and mortality of coronavirus disease 2019: A pooled analysis.Clinical cardiology · 2020Pooled it
- Mortality in COVID-19 patients with acute respiratory distress syndrome and corticosteroids use: a systematic review and meta-analysis.Expert review of respiratory medicine · 2020Pooled it
- Deciphering the Pathogenic Cascade of Acrolein-Induced Lung Injury: From Molecular Insult to Organ Failure.Journal of applied toxicology : JAT · 2026Article
- Ten reasons why acute respiratory failure is different in the immunocompromised host.Intensive care medicine · 2026Article
- Is postoperative ARDS different from medical ARDS?Critical care (London, England) · 2026Article
- Utility of the Thoracic Trauma Severity Score in Predicting Outcomes in Isolated Thoracic Injuries:Sultan Qaboos University medical journal · 2026Observational
- Acute respiratory distress syndrome in patients with cancer: the YELENNA prospective multinational observational cohort study.Intensive care medicine · 2025Observational
- Pro-Reparative Effects of KvLQT1 Potassium Channel Activation in a Mouse Model of Acute Lung Injury Induced by Bleomycin.International journal of molecular sciences · 2025Article
- Impact of ventilatory and laboratory parameter trajectories on short-term survival in acute respiratory distress syndrome patients: a retrospective study using joint models.European journal of medical research · 2025Article
- Risk factors for mortality in children with moderate-to-severe ARDS with concurrent hematological or immune-related diseases: a retrospective analysis.BMC pediatrics · 2025Observational
- Drivers of prognosis and clinical trajectories differ between COVID and non-COVID acute hypoxic respiratory failure.PloS one · 2025Article
- Elevated Hemoglobin A1c and the Risk of Developing ARDS in Two Cohort Studies.CHEST critical care · 2024Article
- Impact of cardiovascular risk factors and cardiac diseases on mortality in patients with moderate to severe ARDS: A retrospective cohort study.International journal of cardiology. Cardiovascular risk and prevention · 2024Article
- Chronic obstructive pulmonary disease affects outcome in surgical patients with perioperative organ injury: a retrospective cohort study in Germany.Respiratory research · 2024Article
- Evaluation of interleukin-1 and interleukin-6 receptor antagonists in a murine model of acute lung injury.Experimental physiology · 2024Article
- Clinical characteristics and risk factors for mortality in pneumonia-associated acute respiratory distress syndrome patients: a single center retrospective cohort study.Frontiers in cellular and infection microbiology · 2024Article
- Outcomes and time trends of acute respiratory distress syndrome patients with and without liver cirrhosis: an observational cohort.Annals of intensive care · 2023Article
- Electrical impedance tomography for titration of positive end-expiratory pressure in acute respiratory distress syndrome patients with chronic obstructive pulmonary disease.Critical care (London, England) · 2022Article
- Veno-venous extracorporeal membrane oxygenation (vv-ECMO) for severe respiratory failure in adult cancer patients: a retrospective multicenter analysis.Intensive care medicine · 2022Article
- Article
Corrections and comments
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Authors and funding
17 authors at 7 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
rationaleThe standard of care for patients with acute respiratory distress syndrome (ARDS) has been developed based on studies that usually excluded patients with major comorbidities.
objectivesTo describe treatments and outcomes according to comorbidities in patients with ARDS admitted to 19 ICUs (1997-2014).
methodsPatients were grouped based on comorbidities. Determinants of day-28 mortality were identified by multivariable Cox analysis stratified on center. MEASUREMENTS AND MAIN
resultsAmong 4953 ARDS patients, 2545 (51.4%) had major comorbidities; the proportion with major comorbidities increased after 2008. Hematological malignancy was associated with severe ARDS and rescue therapies for refractory hypoxemia. COPD, HIV infection, and hematological malignancy were associated with a lower likelihood of invasive mechanical ventilation on the admission day. Admission-day SOFA score was higher in patients with major comorbidities, who more often received vasopressors, dialysis, or treatment-limitation decisions. Day-28 mortality was 33.7% overall, 27.2% in patients without major comorbidities, and 31.1% (COPD) to 56% (hematological malignancy) in patients with major comorbidities. By multivariable analysis, mortality was lower in patients with COPD and higher in those with chronic heart failure, solid tumors, or hematological malignancies. Mortality was independently associated with P
conclusionsHalf the patients with ARDS had major comorbidities, which were associated with severe ARDS, multiple organ dysfunction, and day-28 mortality. These findings do not support the exclusion of ARDS patients with severe comorbidities from randomized clinical trials. Trials in ARDS patients with whatever comorbidities are warranted.
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