ArticleJournal of the Association for Research in Otolaryngology : JARO2018
Effect of Stimulus Polarity on Detection Thresholds in Cochlear Implant Users: Relationships with Average Threshold, Gap Detection, and Rate Discrimination.
Article in Journal of the Association for Research in Otolaryngology : JARO, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 30 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
30 citing papers in PubMed.
- The Interphase Gap Effect in Cochlear Implant Users: Biological Basis, Parameter Selection, Analytical Methods, and Quantitative Scales.Journal of the Association for Research in Otolaryngology : JARO · 2026Article
- Neural Hearing Loss: Mechanisms, Diagnosis and Treatment Horizons.Journal of the Association for Research in Otolaryngology : JARO · 2026Review
- Establishing reliable neural health measures in adult cochlear implant users.Frontiers in neuroscience · 2026Article
- A comparison of electrophysiological measures for characterizing the cochlear-implant electrode-neuron interface.JASA express letters · 2025Article
- Polarity sensitivity to symmetric, biphasic monopolar pulses is not a reliable indicator of peripheral axonal degeneration in human cochlear implant users.Frontiers in audiology and otology · 2025Article
- Effects of selective stimulation of apical electrodes on temporal pitch perception by cochlear implant recipients.The Journal of the Acoustical Society of America · 2024Article
- Artifact removal by template subtraction enables recordings of the frequency following response in cochlear-implant users.Scientific reports · 2024Article
- Insights Into Electrophysiological Metrics of Cochlear Health in Cochlear Implant Users Using a Computational Model.Journal of the Association for Research in Otolaryngology : JARO · 2024Article
- Cochlear Health and Cochlear-implant Function.Journal of the Association for Research in Otolaryngology : JARO · 2023Review
- What Is the Benefit of Ramped Pulse Shapes for Activating Auditory Cortex Neurons? An Electrophysiological Study in an Animal Model of Cochlear Implant.Brain sciences · 2023Article
- Assessing the Relationship Between Pitch Perception and Neural Health in Cochlear Implant Users.Journal of the Association for Research in Otolaryngology : JARO · 2022Article
- Characterizing Polarity Sensitivity in Cochlear Implant Recipients: Demographic Effects and Potential Implications for Estimating Neural Health.Journal of the Association for Research in Otolaryngology : JARO · 2022Article
- Estimating health of the implanted cochlea using psychophysical strength-duration functions and electrode configuration.Hearing research · 2022Article
- Cochlear Implant Research and Development in the Twenty-first Century: A Critical Update.Journal of the Association for Research in Otolaryngology : JARO · 2021Review
- Frequency following responses and rate change complexes in cochlear implant users.Hearing research · 2021Article
- Recovery from forward masking in cochlear implant listeners: Effects of age and the electrode-neuron interface.The Journal of the Acoustical Society of America · 2021Article
- Evaluating and Comparing Behavioural and Electrophysiological Estimates of Neural Health in Cochlear Implant Users.Journal of the Association for Research in Otolaryngology : JARO · 2021Article
- Polarity Sensitivity of Human Auditory Nerve Fibers Based on Pulse Shape, Cochlear Implant Stimulation Strategy and Array.Frontiers in neuroscience · 2021Article
- Electrophysiology and genetic testing in the precision medicine of congenital deafness: A review.Journal of otology · 2021Review
- Effect of the Relative Timing between Same-Polarity Pulses on Thresholds and Loudness in Cochlear Implant Users.Journal of the Association for Research in Otolaryngology : JARO · 2020Article
Corrections and comments
- Erratum issued
Authors and funding
5 authors.
Funding
Abstract
Previous psychophysical and modeling studies suggest that cathodic stimulation by a cochlear implant (CI) may preferentially activate the peripheral processes of the auditory nerve, whereas anodic stimulation may preferentially activate the central axons. Because neural degeneration typically starts with loss of the peripheral processes, lower thresholds for cathodic than for anodic stimulation may indicate good local neural survival. We measured thresholds for 99-pulse-per-second trains of triphasic (TP) pulses where the central high-amplitude phase was either anodic (TP-A) or cathodic (TP-C). Thresholds were obtained in monopolar mode from four or five electrodes and a total of eight ears from subjects implanted with the Advanced Bionics CI. When between-subject differences were removed, there was a modest but significant correlation between the polarity effect (TP-C threshold minus TP-A threshold) and the average of TP-C and TP-A thresholds, consistent with the hypothesis that a large polarity effect corresponds to good neural survival. When data were averaged across electrodes for each subject, relatively low thresholds for TP-C correlated with a high "upper limit" (the pulse rate up to which pitch continues to increase) from a previous study (Cosentino et al. J Assoc Otolaryngol 17:371-382). Overall, the results provide modest indirect support for the hypothesis that the polarity effect provides an estimate of local neural survival.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.