ReviewJournal of neural transmission (Vienna, Austria : 1996)2018
Gene-environment interaction of monoamine oxidase A in relation to antisocial behaviour: current and future directions.
Review in Journal of neural transmission (Vienna, Austria : 1996), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Pooled it
- Type A monoamine oxidase; its unique role in mood, behavior and neurodegeneration.Journal of neural transmission (Vienna, Austria : 1996) · 2025Review
- Differential susceptibility effects of theFrontiers in psychiatry · 2025Article
- Enduring Neurobiological Consequences of Early-Life Stress: Insights from Rodent Behavioral Paradigms.Biomedicines · 2024Review
- Cumulative Genetic Scores Interact with Maternal and Paternal Parenting in Predicting Parent-Adolescent Cohesion and Conflict.Journal of youth and adolescence · 2024Article
- Good parent-child relationship protects against alcohol use in maltreated adolescent females carrying theFrontiers in psychiatry · 2024Article
- Forensic Value of Genetic Variants Associated with Anti-Social Behavior.Diagnostics (Basel, Switzerland) · 2021Review
- Monoaminergic Multilocus Genetic Variants Interact with Stressful Life Events in Predicting Changes in Adolescent Anxiety Symptoms: A One-year Longitudinal Study.Journal of youth and adolescence · 2021Article
- Associations of age, sex, sexual abuse, and genotype with monoamine oxidase a gene methylation.Journal of neural transmission (Vienna, Austria : 1996) · 2021Article
- Three-way interaction effects of early life stress, positive parenting and FKBP5 in the development of depressive symptoms in a general population.Journal of neural transmission (Vienna, Austria : 1996) · 2021Article
- Depressive Symptoms among Middle-Aged Women-Understanding the Cause.Brain sciences · 2020Article
- The role of monoamine oxidase A in the neurobiology of aggressive, antisocial, and violent behavior: A tale of mice and men.Progress in neurobiology · 2020Review
- Single-Dose of Testosterone and theFrontiers in behavioral neuroscience · 2020Article
- Catechol-Frontiers in psychology · 2020Article
- VGLUT2 rs2290045 genotype moderates environmental sensitivity to alcohol-related problems in three samples of youths.European child & adolescent psychiatry · 2019Article
- Emotional stability is associated with the MAOA promoter uVNTR polymorphism in women.Brain and behavior · 2019Article
- Pornography consumption and psychosomatic and depressive symptoms among Swedish adolescents: a longitudinal study.Upsala journal of medical sciences · 2018Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Since the pioneering finding of Caspi and co-workers in 2002 that exposure to childhood maltreatment predicted later antisocial behaviour (ASB) in male carriers of the low-activity MAOA-uVNTR allele, frequent replication studies have been published. Two meta-analyses, one in 2006 and the other in 2014, confirmed the original findings by Caspi and co-workers. In the present paper, we review the literature, note some methodological aspects of candidate gene-environment interaction (cG×E) studies and suggest some future directions. Our conclusions are as follows. (1) The direction of the effect in a cG×E model may differ according to the positive and negative environmental background of the population. (2) There is a predictor-intersection problem such that when measuring one type of maltreatment in a person, other kinds of maltreatment often co-occur. Other forms of abuse are implicitly considered in statistical models; therefore, it is difficult to draw conclusions about the effects of timing and the severity of different forms of stressful life events in relation to ASB. (3) There is also an outcome-intersection problem because of the major intersection of ASB and other forms of mental health problems. It is likely that the G×E with MAOA is related to a common unmeasured factor. (4) For the G×E model, in which the effect of the gene on the outcome variable is dependent on other predictor variables, theoretically, hypothesis-driven statistical modelling is needed.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.