Evidence map›Paper›PMID 29881912›Full record

ArticleForensic science, medicine, and pathology2018

Long QT syndrome KCNH2 mutation with sequential fetal and maternal sudden death.

Jon M Tuveng, Britt-Marie Berling, Gabor Bunford, Carlos G Vanoye, Richard C Welch, Trond P Leren, Alfred L George, Torleiv Ole Rognum

Open access · greenAbstract readCase Reports
PubMed Publisher
In one paragraph

Article in Forensic science, medicine, and pathology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.7field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 2 countries.

Jon M TuvengRingerike Hospital, Hønefoss, Norway.
Britt-Marie BerlingRingerike Hospital, Hønefoss, Norway.
Gabor BunfordRingerike Hospital, Hønefoss, Norway.
Carlos G VanoyeDepartment of Medicine, Vanderbilt University, Nashville, TN, 37232-0275, USA.
Richard C WelchDepartment of Medicine, Vanderbilt University, Nashville, TN, 37232-0275, USA.
Trond P LerenSection of Laboratory Diagnostics, Oslo University Hospital, Oslo, Norway.
Alfred L GeorgeDepartment of Medicine, Vanderbilt University, Nashville, TN, 37232-0275, USA.
Torleiv Ole RognumSection of Forensic Pediatric Medicine, Clinic of Laboratory Medicine, Oslo University Hospital, Oslo, Norway. trognum@ous-hf.no.
Vanderbilt University · USOslo University Hospital · NO

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We report a case of a woman who experienced intrauterine fetal death at full term pregnancy, and then died suddenly soon after learning about the death of her fetus. At autopsy, previously undiagnosed neurofibromatosis and an adrenal gland pheochromocytoma were discovered in the mother. Genetic screening also revealed a novel KCNH2mutation in both fetus and mother indicating type 2 congenital long-QT syndrome (LQTS). A catecholamine surge was suspected as the precipitating event of fetal cardiac arrhythmia and sudden fetal death, while the addition of emotional stress provoked a lethal cardiac event in the mother. This case illustrates the potential for lethal interactions between two occult diseases (pheochromocytoma, LQTS).

Indexed as

Fetal DeathMutationAdrenal Gland NeoplasmsAdultDeath, Sudden, CardiacERG1 Potassium ChannelFemaleHeart ArrestHumansLong QT SyndromeNeurofibromatosesPheochromocytomaPregnancyERG1 Potassium ChannelKCNH2 protein, humanLong QT syndromeNeurofibromatosisPheochromocytomaSudden intrauterine deathSudden maternal death in pregnancy

Identifiers

PMID29881912
OpenAlexW2805884178

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.