Evidence map›Paper›PMID 29881810›Full record

ArticleEpilepsia open2018

Facilitation of kindling epileptogenesis by chronic stress may be mediated by intestinal microbiome.

Jesús-Servando Medel-Matus, Don Shin, Edward Dorfman, Raman Sankar, Andrey Mazarati

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Epilepsia open, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 62 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
62citing papers in PubMed, 2 pooled it
3.2field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

62 citing papers in PubMed, 2 syntheses or guidelines pooled it, 100 citations in OpenAlex.

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2 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Jesús-Servando Medel-MatusDepartment of Pediatrics David Geffen School of Medicine at UCLA Los Angeles California U.S.A.
Don ShinDepartment of Pediatrics David Geffen School of Medicine at UCLA Los Angeles California U.S.A.
Edward DorfmanDepartment of Pediatrics David Geffen School of Medicine at UCLA Los Angeles California U.S.A.
Raman SankarDepartment of Pediatrics David Geffen School of Medicine at UCLA Los Angeles California U.S.A.
Andrey MazaratiDepartment of Pediatrics David Geffen School of Medicine at UCLA Los Angeles California U.S.A.
University of California, Los Angeles · US

Funding

Mechanisms of comorbidity between epilepsy and depressionR01NS065783 · NINDS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI MAZARATI, ANDREY M · 2010 to 2017
$2.9M
NINDS NIH HHS R01 NS065783
6 · The paper itself

Abstract

There has been growing interest in the role of intestinal microbiome in brain disorders. We examined whether dysbiosis can predispose to epilepsy. The study was performed in female and male Sprague-Dawley rats. To induce dysbiosis, the rats were subjected to chronic restraint stress (two 2-h long sessions per day, over 2 weeks). Cecal content from stressed and sham-stressed donors was transplanted via oral gavage to recipients, in which commensal microbiota had been depleted by the antibiotics. The study included the following groups: (1) Sham stress, no microbiota transplant; (2) Stress, no microbiota transplant; (3) Sham-stressed recipients transplanted with microbiota from sham-stressed donors; (4) Stressed recipients transplanted with microbiota from sham-stressed donors; (5) Sham-stressed recipients transplanted with microbiota from stressed donors; and (6) Stressed recipients transplanted with microbiota from stressed donors. After microbiota transplant, all animals were subjected to kindling of the basolateral amygdala. Both chronic stress and microbiome transplanted from stressed to sham-stressed subjects accelerated the progression and prolonged the duration of kindled seizures. Microbiome from sham-stressed animals transplanted to chronically stressed rats, counteracted proepileptic effects of restraint stress. These findings directly implicate perturbations in the gut microbiome, particularly those associated with chronic stress, in the increased susceptibility to epilepsy.

Indexed as

BrainDysbiosisEpilepsyMicrobiota

Identifiers

PMID29881810
PMCPMC5983141
OpenAlexW2805633350

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.