Evidence map›Paper›PMID 29881797›Full record

ArticleEpilepsia open2018

Optimal clinical management of children receiving dietary therapies for epilepsy: Updated recommendations of the International Ketogenic Diet Study Group.

Eric H Kossoff, Beth A Zupec-Kania, Stéphane Auvin, Karen R Ballaban-Gil, A G Christina Bergqvist, Robyn Blackford, Jeffrey R Buchhalter, Roberto H Caraballo, J Helen Cross, Maria G Dahlin and 24 more

6 registry-linked trialsOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Epilepsia open, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 6 registered trials, which are not on this map. Cited by 327 papers, 14 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
327citing papers in PubMed, 14 pooled it
33.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04358835 nawithdrawnnot on this mapstarted 2020, after this paper: background citation

Keto-diet for Intubated Critical Care COVID-19 (KICC-COVID19)

TypeinterventionalSponsorJohns Hopkins UniversityRan2020 to 2021Enrolled0ConditionsCOVID-19ArmsKetogenic diet, standard of care
NCT05512130 early_phase1unknown statusnot on this mapstarted 2022, after this paper: background citation

Sodium-Glucose Cotransporter-2 Inhibitors: A Potential Novel Treatment for Epilepsy

TypeinterventionalSponsorWashington University School of MedicineRan2022 to 2023Enrolled18ConditionsEpilepsyArmsEmpagliflozin 25 mg, Placebo
NCT06309251 recruitingnot on this mapstarted 2022, after this paper: background citation

Clinical and Nutritional Effectiveness and Impact on the Quality of Life of the Ketogenic Diet in Pediatric Patients With Neurological, Genetic or Metabolic Disorders: a Multicenter Prospective Observational Study

TypeobservationalSponsorDanone Nutricia SpA Società BenefitRan2022 to 2026Enrolled100ConditionsDrug Resistant Epilepsy, Autism Spectrum Disorder, Chronic Migraine, Brain Tumor, PediatricArmsketogenic diet (as per clinical practice)
NCT06715436 narecruitingnot on this mapstarted 2024, after this paper: background citation

The Effects of Ketogenic Diet Therapy Versus the Mediterranean Diet on Quality of Life in a Group of Patients With Multiple Sclerosis - the KETOMED-MS Study

TypeinterventionalSponsorIRCCS National Neurological Institute "C. Mondino" FoundationRan2024 to 2025Enrolled111ConditionsMultiple Sclerosis, Relapsing-RemittingArmsMediterranean Diet, Ketogenic Diet, Control group
NCT06920940 narecruitingnot on this mapstarted 2025, after this paper: background citation

Child Bipolar Network Ketogenic Diet Approach to Bipolar Disorder in Adolescents

TypeinterventionalSponsorUniversity of California, Los AngelesRan2025 to 2027Enrolled80ConditionsBipolar Disorder (BD), Bipolar Disorder NOS, Bipolar Disorder I or II, Bipolar Spectrum DisorderArmsKetogenic Therapy
NCT07714226 active not recruitingnot on this mapstarted 2023, after this paper: background citation

A Multifaceted Assessment of Eating Behaviors, Anthropometric Measurements and Body Composition in Pediatric Patients With Drug-resistant Epilepsy on a Ketogenic Diet and Healthy Children

TypeobservationalSponsorWroclaw Medical UniversityRan2023 to 2027Enrolled150ConditionsEpilepsy Intractable
3 · Its place in the literature

Who cites it

327 citing papers in PubMed, 14 syntheses or guidelines pooled it, 707 citations in OpenAlex.

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  15. Trial
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  19. Management of ketogenic diet therapy in patients with ileostomy: A report of 2 cases.Nutrition in clinical practice : official publication of the American Society for Parenteral and Enteral Nutrition · 2026
    Article
  20. Article

267 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

34 authors at 20 institutions in 13 countries.

Eric H KossoffDepartments of Neurology and Pediatrics Johns Hopkins Outpatient Center Baltimore Maryland U.S.A.
Beth A Zupec-KaniaThe Charlie Foundation Santa Monica California U.S.A.
Stéphane AuvinDepartment of Pediatric Neurology CHU Hôpital Robert Debré Paris France.ORCID 0000-0003-3874-9749
Karen R Ballaban-GilDepartment of Neurology and Pediatrics Montefiore Medical Center/Albert Einstein College of Medicine Bronx New York U.S.A.
A G Christina BergqvistDepartment of Neurology The Childrens Hospital of Philadelphia Philadelphia Pennsylvania U.S.A.
Robyn BlackfordDepartment of Nutrition Lurie Children's Hospital Chicago Illinois U.S.A.
Jeffrey R BuchhalterDepartment of Pediatrics Alberta Children's Hospital Calgary Alberta Canada.
Roberto H CaraballoDepartment of Neurology Hospital J P Garrahan, Capital Federal Buenos Aires Argentina.ORCID 0000-0003-0259-1046
J Helen CrossDepartment of Clinical & Experimental Epilepsy Great Ormond Street Hospital University College London London United Kingdom.
Maria G DahlinDepartment of Clinical Neuroscience, Women's and Children's Health Karolinska Institute Stockholm Sweden.
Elizabeth J DonnerDivision of Neurology The Hospital for Sick Children Toronto Ontario Canada.
Orkide GuzelDepartment of Pediatric Neurology Izmir Dr. Behcet Uz Children's Hospital Izmir Turkey.
Rana S JehleDepartment of Neurology Montefiore Medical Center Bronx New York U.S.A.
Joerg KlepperDepartment of Pediatrics and Neuropediatrics Children's Hospital Aschaffenburg Aschaffenburg Germany.
Hoon-Chul KangDepartment of Pediatrics Pediatric Epilepsy Clinic Severance Children's Hospital Seoul Korea.
Danielle A LambrechtsDepartment of Neurology Epilepsy Centre Kempenhaeghe Heeze The Netherlands.
Y M Christiana LiuDepartment of Neurology The Hospital for Sick Children Toronto Ontario Canada.
Janak K NathanDepartment of Child Neurology Shushrusha Hospital Mumbai India.
Douglas R NordliDepartment of Neurology Children's Hospital of Los Angeles Los Angeles California U.S.A.
Heidi H PfeiferDepartment of Neurology Massachusetts General Hospital Boston Massachusetts U.S.A.
Jong M RhoDepartment of Paediatrics Alberta Children's Hospital Calgary Alberta Canada.
Ingrid E SchefferEpilepsy Research Centre The University of Melbourne Austin Health Heidelberg Victoria Australia.
Suvasini SharmaDepartment of Pediatrics Lady Hardinge Medical College New Delhi India.
Carl E StafstromDepartments of Pediatrics and Neurology Johns Hopkins Hospital Baltimore Maryland U.S.A.
Elizabeth A ThieleDepartment of Neurology Massachusetts General Hospital Boston Massachusetts U.S.A.
Zahava TurnerDepartment of Pediatrics The Johns Hopkins University Baltimore Maryland U.S.A.
Maria M VaccarezzaDepartment of Neurology Hospital Italiano de Buenos Aires Buenos Aires Argentina.
Elles J T M van der LouwDepartment of Dietetics Sophia Children's Hospital Erasmus Medical Centre Rotterdam The Netherlands.
Pierangelo VeggiottiInfantile Neuropsychiatry Neurological Institute Foundation Casimiro Mondino Pavia Italy.
James W WhelessDepartment of Pediatric Neurology University of Tennessee Memphis Tennessee U.S.A.
Elaine C WirrellDepartment of Neurology, Child and Adolescent Neurology Mayo Clinic Rochester Minnesota U.S.A.
Charlie Foundation
Matthew's Friends
Practice Committee of the Child Neurology Society
Alberta Children's Hospital · CAHospital for Sick Children · CAJohns Hopkins University · USMassachusetts General Hospital · USAlbert Einstein College of Medicine · USAngeles Clinic Foundation · USChildren's Hospital of Los Angeles · USChildren's Hospital of Philadelphia · USDr. Behçet Uz Çocuk Hastalıkları Hastanesi · TRErasmus MC - Sophia Children’s Hospital · NLFondazione Istituto Neurologico Nazionale Casimiro Mondino · ITGarrahan Hospital · ARGreat Ormond Street Hospital · GBHôpital Robert-Debré · FRHospital Italiano de Buenos Aires · ARJohns Hopkins Hospital · USKarolinska Institutet · SEKempenhaeghe · NLKlinikum Aschaffenburg · DELady Hardinge Medical College · IN

Funding

Medical Research Council MC_PC_14140
6 · The paper itself

Abstract

Ketogenic dietary therapies (KDTs) are established, effective nonpharmacologic treatments for intractable childhood epilepsy. For many years KDTs were implemented differently throughout the world due to lack of consistent protocols. In 2009, an expert consensus guideline for the management of children on KDT was published, focusing on topics of patient selection, pre-KDT counseling and evaluation, diet choice and attributes, implementation, supplementation, follow-up, side events, and KDT discontinuation. It has been helpful in outlining a state-of-the-art protocol, standardizing KDT for multicenter clinical trials, and identifying areas of controversy and uncertainty for future research. Now one decade later, the organizers and authors of this guideline present a revised version with additional authors, in order to include recent research, especially regarding other dietary treatments, clarifying indications for use, side effects during initiation and ongoing use, value of supplements, and methods of KDT discontinuation. In addition, authors completed a survey of their institution's practices, which was compared to responses from the original consensus survey, to show trends in management over the last 10 years.

Indexed as

ChildrenDietEpilepsyGuidelineKetogenic

Identifiers

PMID29881797
PMCPMC5983110
OpenAlexW2800663093

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.