ArticleAvicenna journal of phytomedicine
Protective effect of
Article in Avicenna journal of phytomedicine. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
3 citing papers in PubMed.
- Review
- Synergistic effect of endurance training and nettle leaf extract on the IDO1-KYN-AHR pathway homeostasis and inhibiting of liver toxicity in rats with STZ-induced diabetes.Frontiers in endocrinology · 2023Article
- Application of Ultrasound as Clean Technology for Extraction of Specialized Metabolites From Stinging Nettle (Frontiers in nutrition · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveFinding compounds that could be used for prevention of atherosclerosis (AS) is highly desired. The present study evaluated the protective effects of MATERIALS AND
methodsIn this study, 40 male adult Sprauge-Dawley rats were randomly allocated to 4 equal groups and treated as follows for 9 consecutive weeks: (1) Normal control (NC; normal rats that were fed with a basic diet); (2) Atherosclerotic rats (AT; which received no particular treatment); (3) Atherosclerotic rats that received 100 mg/kg/day ethanolic extract of UD orally and (4) Atherosclerotic rats that received simvastatin 4 mg/kg/day orally. Atherosclerosis was induced by a high-fat diet accompanied by propylthiouracil and vitamin D3.
resultsMarked hypercholesterolemia and significant increase in LDL-C/HDL-C ratio were observed in rats of AT group. Administration of UD significantly reduced these parameters as compared to AT group (p<0.05 for all cases). In histopathological evaluations of the aortic arch, AT rats showed atherosclerotic lesions, which were markedly ameliorated in rats treated with UD or simvastatin. Simvastatin and UD significantly reduced medial (p<0.05) but not intimal thickness. Increased level of malondialdehyde (MDA) and reduced total antioxidant capacity (TAC) were observed in the aortic arch of AT rats (p<0.05 for all cases). In contrast with simvastatin, UD extract had no significant effect on these parameters.
conclusionEthanolic extract of UD prevents establishment of atherosclerotic lesions in rat aorta, which is associated with positive effects on serum lipid profile without significantly affecting antioxidant status.
Indexed as
Identifiers
29881711PMC5987440What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.