ArticleQuantitative biology (Beijing, China)2018
Systems and synthetic biology approaches in understanding biological oscillators.
Article in Quantitative biology (Beijing, China), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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15 citing papers in PubMed.
- Control-guided refinement of partially specified Boolean networks: applications to RTK signaling.Bioinformatics (Oxford, England) · 2026Article
- A tool for modeling gene regulatory networks (GRN_modeler) and its applications to synthetic biology.Molecular systems biology · 2025Article
- Autonomous Dynamic Control of Crown Ether Cargo Release from [2]Rotaxane Carriers in a Piperidine Oscillator.Journal of the American Chemical Society · 2025Article
- Review
- From resonance to chaos by modulating spatiotemporal patterns through a synthetic optogenetic oscillator.Nature communications · 2024Article
- An oscillating reaction network with an exact closed form solution in the time domain.BMC bioinformatics · 2023Article
- Efficient, Formal, Material, and Final Causes in Biology and Technology.Entropy (Basel, Switzerland) · 2023Article
- Robustness and reproducibility of simple and complex synthetic logic circuit designs using a DBTL loop.Synthetic biology (Oxford, England) · 2023Article
- What Makes a Functional Gene Regulatory Network? A Circuit Motif Analysis.The journal of physical chemistry. B · 2022Article
- Combined multiple transcriptional repression mechanisms generate ultrasensitivity and oscillations.Interface focus · 2022Article
- Temporal control of the integrated stress response by a stochastic molecular switch.Science advances · 2022Article
- Oscillating the local milieu of polymersome interiors via single input-regulated bilayer crosslinking and permeability tuning.Nature communications · 2022Article
- Synthetic Protein Circuits and Devices Based on Reversible Protein-Protein Interactions: An Overview.Life (Basel, Switzerland) · 2021Review
- Circadian rhythms and the HPA axis: A systems view.WIREs mechanisms of disease · 2021Review
- The social nature of mitochondria: Implications for human health.Neuroscience and biobehavioral reviews · 2021Review
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2 authors.
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Abstract
backgroundSelf-sustained oscillations are a ubiquitous and vital phenomenon in living systems. From primitive single-cellular bacteria to the most sophisticated organisms, periodicities have been observed in a broad spectrum of biological processes such as neuron firing, heart beats, cell cycles, circadian rhythms, etc. Defects in these oscillators can cause diseases from insomnia to cancer. Elucidating their fundamental mechanisms is of great significance to diseases, and yet challenging, due to the complexity and diversity of these oscillators.
resultsApproaches in quantitative systems biology and synthetic biology have been most effective by simplifying the systems to contain only the most essential regulators. Here, we will review major progress that has been made in understanding biological oscillators using these approaches. The quantitative systems biology approach allows for identification of the essential components of an oscillator in an endogenous system. The synthetic biology approach makes use of the knowledge to design the simplest,
conclusionWith the recent development of biological and computational tools, both approaches have made significant achievements.
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