ArticleJournal of clinical urology2018
Improving the safety and tolerability of local anaesthetic outpatient transperineal prostate biopsies: A pilot study of the CAMbridge PROstate Biopsy (CAMPROBE) method.
Article in Journal of clinical urology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02375035 (Developing a Safer and More Accurate Device for Biopsies of Suspected Prostate Cancer), which is not on this map. Cited by 16 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Developing a Safer and More Accurate Device for Biopsies of Suspected Prostate Cancer
Who cites it
16 citing papers in PubMed, 33 citations in OpenAlex.
- Comparative Performance of the CamPROBE Local Anaesthetic Transperineal Biopsy Device Versus an In-Line Device for Detection of Significant Prostate Cancer.Journal of clinical medicine · 2025Article
- Transperineal prostate biopsy with freehand technique under local anaesthetic: A systematic review and meta-analysis.BJUI compass · 2025Review
- A cost-effective transperineal prostate biopsy method utilizes the original transrectal setting.International urology and nephrology · 2023Article
- Freehand transperineal prostate biopsy with a coaxial needle under local anesthesia: Experience from a single institution in Malaysia.Cancer pathogenesis and therapy · 2023Article
- Comparing outcomes of transperineal to transrectal prostate biopsies performed under local anaesthesia.BJUI compass · 2022Article
- Transperineal ultrasound-guided prostate biopsy: what the radiologist needs to know.Insights into imaging · 2022Review
- Role of Prophylactic Antibiotics in Transperineal Prostate Biopsy: A Systematic Review and Meta-analysis.European urology open science · 2022Review
- Safety profile of robotic-assisted transperineal MRI-US-fusion guided biopsy of the prostate.Frontiers in oncology · 2022Article
- Local versus general anesthesia transperineal prostate biopsy: Tolerability, cancer detection, and complications.BJUI compass · 2021Article
- Rationale and protocol for randomized study of transrectal and transperineal prostate biopsy efficacy and complications (ProBE-PC study).Prostate cancer and prostatic diseases · 2021Review
- Rebiopsy rate after transperineal or transrectal prostate biopsy.Prostate international · 2021Article
- Sectoral cancer detection and tolerability of freehand transperineal prostate biopsy under local anaesthesia.Prostate cancer and prostatic diseases · 2021Article
- Magnetic resonance imaging-guided prostate biopsy-A review of literature.Asian journal of urology · 2021Review
- Recent Advances in Systematic and Targeted Prostate Biopsies.Research and reports in urology · 2021Review
- Multicentre clinical evaluation of the safety and performance of a simple transperineal access system for prostate biopsies for suspected prostate cancer: The CAMbridge PROstate Biopsy DevicE (CamPROBE) study.Journal of clinical urology · 2020Article
- Feasibility of freehand MRI/US cognitive fusion transperineal biopsy of the prostate in local anaesthesia as in-office procedure-experience with 400 patients.Prostate cancer and prostatic diseases · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
objectivesThe aim of this study was to pilot the use of a bespoke device (CAMPROBE, the CAMbridge PROstate Biopsy) to enable routine outpatient free-hand local anaesthetic (LA) transperineal prostate biopsies. MATERIALS AND
methodsThe CAMPROBE prototype was designed and built in our institution. Men on active surveillance due prostate resampling were invited to have a CAMPROBE biopsy as an alternative to repeat transrectal ultrasound-guided prostate biopsies (TRUSBx) as part of an approved trial (NCT02375035). Biopsies were performed using LA infiltration only, without sedation or additional analgesia. Patient-reported outcomes were recorded at day 0 and 7 using validated questionnaires and visual analogue scales (VAS). Complications were recorded prospectively.
resultsThirty men underwent biopsies with a median of 11 cores taken per procedure (interquartile range 10-12). There were no infections, sepsis or retention episodes. Haematuria and haematospermia occurred in 67% and 62% of patients, which are similar to rates reported for TRUSBx. Mean VAS for pain (0-10 scale) was less than 3 for every part of the procedure. All 30 men described the procedure as tolerable under LA. In total, 26/30 (86.7%) men expressed a preference for a CAMPROBE procedure over TRUSBx and a further 3 (10.0%) would have either.
conclusionsIn this small pilot study, the CAMPROBE device and method appears to be a safe, simple and well-tolerated out-patient transperineal replacement for TRUSBx. A major new National Institute for Health Research grant will allow its further development from a prototype to a single use, low-cost disposable device ready for multi-centre testing. LEVEL OF EVIDENCE: 1b: individual cohort study.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.