ArticleUnited European gastroenterology journal2018
Propofol sedation during gastrointestinal endoscopy arouses euphoria in a large subset of patients.
Article in United European gastroenterology journal, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06721195 (A Cross-Sectional Study on Euphoria Induced by Remimazolam During Gastrointestinal Endoscopy and Its Related Factors), which is not on this map. Cited by 24 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
A Cross-Sectional Study on Euphoria Induced by Remimazolam During Gastrointestinal Endoscopy and Its Related Factors
Who cites it
24 citing papers in PubMed, 50 citations in OpenAlex.
- Repeated remimazolam sedation for interstitial brachytherapy in cervical cancer: a randomized controlled trial.Annals of medicine · 2026Trial
- Optimal remimazolam dosage for pediatric painless gastrointestinal endoscopy: a randomized controlled trial comparing efficacy and safety of three doses combined with sufentanil and propofol.BMC anesthesiology · 2026Trial
- Trial
- Capnography-detected respiratory depression during procedural sedation with remimazolam versus propofol: a randomised trial.Scientific reports · 2025Trial
- Influences of Propofol, Ciprofol and Remimazolam on Dreaming During Anesthesia for Gastrointestinal Endoscopy: A Randomized Double-Blind Parallel-Design Trial.Drug design, development and therapy · 2024Trial
- Comparison of the impact of propofol versus sevoflurane on early postoperative recovery in living donors after laparoscopic donor nephrectomy: a prospective randomized controlled study.BMC anesthesiology · 2020Trial
- [Repetitive intentional foreign body ingestion: Risk of abuse of propofol in endoscopic procedures].Der Nervenarzt · 2026Review
- Integration of epidemiological surveys, network pharmacology, and molecular docking simulation to explore the potential key targets of propofol-induced euphoria.Naunyn-Schmiedeberg's archives of pharmacology · 2026Article
- Advantages of Ciprofol with Special Consideration of Pediatric Anesthesia.Children (Basel, Switzerland) · 2026Review
- Effects of intravenous propofol combined with opioids on euphoria in patients undergoing painless gastrointestinal endoscopy: protocol for a randomized double-blind placebo-controlled trial.Frontiers in pharmacology · 2025Article
- Selective impairment and a positive recognition bias of the facial emotion recognition after propofol anesthesia during gastrointestinal endoscopy.Frontiers in psychology · 2025Article
- Electroencephalogram prediction of propofol effects on neuromodulation in disorders of consciousness.Frontiers in neurology · 2025Article
- Effect of ciprofol compared with propofol on hemodynamics in bronchoscope procedures during anesthetic induction: a randomized double-blind controlled study.Frontiers in medicine · 2025Article
- General anesthesia activates a central anxiolytic center in the BNST.Cell reports · 2024Article
- Propofol Alleviates Anxiety-Like Behaviors Associated with Pain by Inhibiting the Hyperactivity of PVNAdvanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- Article
- Propofol Brings on the Light for Depression Therapy.Neuroscience bulletin · 2023Article
- General anesthetic action profile on the human prefrontal cortex cells through comprehensive single-cell RNA-seq analysis.iScience · 2023Article
- Propofol misuse in medical professions: a scoping review.Canadian journal of anaesthesia = Journal canadien d'anesthesie · 2023Article
- Factors associated with euphoria in a large subset of cases using propofol sedation during gastrointestinal endoscopy.Frontiers in psychiatry · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPropofol is recommended for sedation in gastrointestinal endoscopy (GE), but preliminary data suggest addictive potentials.
objectiveThe objective of this article is to evaluate the frequency of predominantly euphoric reaction after GE and patients' subsequent reminiscences.
methodsEighty-two patients undergoing elective GE under propofol sedation were enrolled in a prospective observational study. The grade of anxiety, expectation or relief about the examination's result and affective state in terms of cheerfulness, relaxation, activation, sedation and anxiety were surveyed using a numeric rating scale (1 to 10) immediately before (t1), after GE (t2) and seven days (t3) later. Statistics: hierarchical cluster analysis, heat map, χ2 test and paired
resultsMean propofol dosage was 264 ± 120 mg. Two clusters of mood changes emerged (t1 vs. t2). One (
conclusionPropofol induces euphoria in nearly half of the patients undergoing elective GE with persisting, even enhanced reminiscence (germanctr.de, trial number DRKS00011202).
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.