ArticleFrontiers in immunology2018
Estrogen Receptor-Alpha (ESR1) Governs the Lower Female Reproductive Tract Vulnerability to
Article in Frontiers in immunology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
23 citing papers in PubMed, 41 citations in OpenAlex.
- Rethinking Vaginal Microbiome Resilience: A Conceptual Multi-Omic Framework.Microorganisms · 2026Review
- An IL-1, IL-17, and IL-22 cytokine circuit controls vulvovaginal candidiasis independently of estrogen.PLoS pathogens · 2026Article
- Effect of bacterial vaginosis on induced labour in the third trimester of pregnancy: a retrospective cohort study.BMC pregnancy and childbirth · 2026Article
- Immune modulation by sex hormones: unveiling the complex interplay and regulatory networks.Frontiers in immunology · 2026Review
- The importance of ovary-immune interactions in the context of age and disease.Frontiers in neuroendocrinology · 2026Review
- Vaginal epithelial estrogen receptor α coordinates glycogen deposition, microbial stability, and pH regulation in mice.bioRxiv : the preprint server for biology · 2025Article
- Progesterone promotes CXCl2-dependent vaginal neutrophil killing by activating cervical resident macrophage-neutrophil crosstalk.JCI insight · 2024Article
- Development and Evaluation of Microencapsulated Oregano Essential Oil as an Alternative Treatment forACS applied materials & interfaces · 2024Article
- Cracking the Code: Investigating the Correlation between Aerobic Vaginitis and Preterm Labor.Medicina (Kaunas, Lithuania) · 2024Review
- Differential expression of HIV target cells CCR5 and α4β7 in tissue resident memory CD4 T cells in endocervix during the menstrual cycle of HIV seronegative women.Frontiers in immunology · 2024Article
- The Biological Significance of Trogocytosis.Results and problems in cell differentiation · 2024Article
- Nonoptimal bacteria species induce neutrophil-driven inflammation and barrier disruption in the female genital tract.Mucosal immunology · 2023Article
- The Medium Is the Message: Defining a "Normal" Vaginal Microbiome in Healthy Reproductive-Age Women.Reproductive sciences (Thousand Oaks, Calif.) · 2023Article
- Dual wave of neutrophil recruitment determines the outcome ofFrontiers in cellular and infection microbiology · 2023Article
- Pathogenesis and virulence ofVirulence · 2022Review
- Sex-the most underappreciated variable in research: insights from helminth-infected hosts.Veterinary research · 2022Review
- The role of estrogen in circular RNA and metabonomics in aAnnals of translational medicine · 2022Article
- Estrogen promotes innate immune evasion of Candida albicans through inactivation of the alternative complement system.Cell reports · 2022Article
- Vaginal neutrophil infiltration is contingent on ovarian cycle phase and independent of pathogen infection.Frontiers in immunology · 2022Article
- Mixed Vaginitis in the Third Trimester of Pregnancy Is Associated With Adverse Pregnancy Outcomes: A Cross-Sectional Study.Frontiers in cellular and infection microbiology · 2022Article
Corrections and comments
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Authors and funding
15 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Estradiol-based therapies predispose women to vaginal infections. Moreover, it has long been known that neutrophils are absent from the vaginal lumen during the ovulatory phase (high estradiol). However, the mechanisms that regulate neutrophil influx to the vagina remain unknown. We investigated the neutrophil transepithelial migration (TEM) into the vaginal lumen. We revealed that estradiol reduces the CD44 and CD47 epithelial expression in the vaginal ectocervix and fornix, which retain neutrophils at the apical epithelium through the estradiol receptor-alpha. In contrast, luteal progesterone increases epithelial expression of CD44 and CD47 to promote neutrophil migration into the vaginal lumen and
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.