Evidence map›Paper›PMID 29881374›Full record

ArticleFrontiers in immunology2018

C5a Blockade Increases Regulatory T Cell Numbers and Protects Against Microvascular Loss and Epithelial Damage in Mouse Airway Allografts.

Mohammad Afzal Khan, Fatimah Alanazi, Hala Abdalrahman Ahmed, Axel Vater, Abdullah Mohammed Assiri, Dieter Clemens Broering

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
0.8field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 24 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Mohammad Afzal KhanComparative Medicine Department, King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia.
Fatimah AlanaziComparative Medicine Department, King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia.
Hala Abdalrahman AhmedComparative Medicine Department, King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia.
Axel VaterAptarion Biotech AG, Berlin, Germany.
Abdullah Mohammed AssiriComparative Medicine Department, King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia.
Dieter Clemens BroeringOrgan Transplant Centre, King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia.
King Faisal Specialist Hospital & Research Centre · SAAptar (Germany) · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Microvascular injury during acute rejection has been associated with massive infiltration of CD4

Indexed as

AllograftsAnimalsComplement C5aEpithelial CellsGraft RejectionImmune ToleranceImmunosuppressive AgentsMiceMice, Inbred BALB CMice, Inbred C57BLMicrovesselsRespiratory SystemT-Lymphocytes, RegulatoryTracheaTransplantation, HomologousComplement C5aImmunosuppressive Agentsairway allograftsC5a blockingimmunosuppressionmicrovascular reestablishmentTreg induction

Identifiers

PMID29881374
PMCPMC5976734
OpenAlexW2799897429

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.