Evidence map›Paper›PMID 29881346›Full record

ArticleFrontiers in aging neuroscience2018

Infection of Fungi and Bacteria in Brain Tissue From Elderly Persons and Patients With Alzheimer's Disease.

Ruth Alonso, Diana Pisa, Ana M Fernández-Fernández, Luis Carrasco

Open access · goldAbstract read
In one paragraph

Article in Frontiers in aging neuroscience, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 104 papers.

0numbers the graph read from it
0cells of the map it votes in
104citing papers in PubMed
6.1field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

104 citing papers in PubMed, 164 citations in OpenAlex.

  1. Review
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  9. A Review on the Pathophysiology of Alzheimer's Disease.Current protein & peptide science · 2026
    Review
  10. Review
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  12. Review
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  14. LivemBio · 2025
    Article
  15. Article
  16. Review
  17. Review
  18. Possible link betweenAfrican health sciences · 2025
    Article
  19. Article
  20. Alzheimer's Disease andLife (Basel, Switzerland) · 2025
    Review

44 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Ruth AlonsoCentro de Biología Molecular "Severo Ochoa", Consejo Superior de Investigaciones Científicas y Universidad Autónoma de Madrid, Madrid, Spain.
Diana PisaCentro de Biología Molecular "Severo Ochoa", Consejo Superior de Investigaciones Científicas y Universidad Autónoma de Madrid, Madrid, Spain.
Ana M Fernández-FernándezCentro de Biología Molecular "Severo Ochoa", Consejo Superior de Investigaciones Científicas y Universidad Autónoma de Madrid, Madrid, Spain.
Luis CarrascoCentro de Biología Molecular "Severo Ochoa", Consejo Superior de Investigaciones Científicas y Universidad Autónoma de Madrid, Madrid, Spain.
Universidad Autónoma de Madrid · ES

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Alzheimer's disease (AD) is the leading cause of dementia in elderly people. The etiology of this disease remains a matter of intensive research in many laboratories. We have advanced the idea that disseminated fungal infection contributes to the etiology of AD. Thus, we have demonstrated that fungal proteins and DNA are present in nervous tissue from AD patients. More recently, we have reported that bacterial infections can accompany these mycoses, suggesting that polymicrobial infections exist in AD brains. In the present study, we have examined fungal and bacterial infection in brain tissue from AD patients and control subjects by immunohistochemistry. In addition, we have documented the fungal and bacterial species in brain regions from AD patients and control subjects by next-generation sequencing (NGS). Our results from the analysis of ten AD patients reveal a variety of fungal and bacterial species, although some were more prominent than others. The fungal genera more prevalent in AD patients were

Indexed as

Alzheimer’s diseasebacteria and fungal co-infectionsfungal infectioninfection in aging brainnext generation sequencingpolymicrobial infection

Identifiers

PMID29881346
PMCPMC5976758
OpenAlexW2802500969

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.