ArticleFood & nutrition research2018
Maternal and early-life vitamin D deficiency enhances allergic reaction in an ovalbumin-sensitized BALB/c mouse model.
Article in Food & nutrition research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 31 citations in OpenAlex.
- Relationship between vitamin D and IgE: a cross-sectional analysis.Translational pediatrics · 2026Article
- Prenatal vitamin D deficiency exposure leads to long-term changes in immune cell proportions.Scientific reports · 2024Article
- Serum vitamin D status in a cohort of infants with food protein‑induced gastrointestinal disease.Biomedical reports · 2023Article
- Evaluating the effects of vitamin D Level on airway obstruction in two asthma endotypes in humans and in two mouse models with different intake of vitamin D during early-life.Frontiers in immunology · 2023Article
- Mast Cells and Vitamin D Status: A Clinical and Biological Link in the Onset of Allergy and Bone Diseases.Biomedicines · 2022Review
- The Role of Vitamin D in Alzheimer's Disease: A Transcriptional Regulator of Amyloidopathy and Gliopathy.Biomedicines · 2022Article
- Nutrition during Pregnancy and Lactation: Epigenetic Effects on Infants' Immune System in Food Allergy.Nutrients · 2022Review
- Correlation between vitamin D levels and bone metabolism in children with cow's milk allergy.The Journal of international medical research · 2022Article
- A narrative review of vitamin D and food allergy in infants and children.Translational pediatrics · 2021Review
- Decreased Serum 25-(OH)-D Level Associated With Muscle Enzyme and Myositis Specific Autoantibodies in Patients With Idiopathic Inflammatory Myopathy.Frontiers in immunology · 2021Observational
- Advances in Molecular Mechanisms of Wheat Allergenicity in Animal Models: A Comprehensive Review.Molecules (Basel, Switzerland) · 2019Review
- Mouse Chow Composition Influences Immune Responses and Food Allergy Development in a Mouse Model.Nutrients · 2018Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundRecent studies have shown that vitamin D deficiency may contribute to the high prevalence of food allergy but the underlying mechanisms are far from clear.
objectiveThe present study was designed to investigate the effect of maternal and early-life vitamin D deficiency in the development of food allergy.
designBALB/c mice were treated with ovalbumin (OVA) to trigger allergic reactions, under vitamin D-deficient (by maternal and early-life feeding of vitamin D deprived chow diet) or vitamin D-sufficient conditions.
resultsIncreased occurrence and severity of allergic diarrhea as well as decreased rectal temperature were observed after OVA sensitization. For vitamin D deficiency groups, OVA-specific IgE and IL-4 levels were significantly increased, while IFN-γ levels were unchanged. Vitamin D deficiency also attenuated the structure of small intestinal villi and decreased the expression of the tight junction protein between adjacent epithelial cells and the percentages of CD4
conclusionsMaternal and early-life vitamin D deficiency have notable influence on the susceptibility to food allergy, which may relate with the reduced population of Treg cell and the dysfunction of intestinal epithelial barrier.
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