ArticleInternational journal of chronic obstructive pulmonary disease2018
Chronic cough as a novel phenotype of chronic obstructive pulmonary disease.
Article in International journal of chronic obstructive pulmonary disease, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Management of Cough in Patients with Chronic Obstructive Pulmonary Disease: Results of the Multicenter Randomized Placebo-Controlled Clinical Trial.International journal of chronic obstructive pulmonary diseaseTrial
- Association of respiratory symptom profiles with future exacerbations and lung function decline in mild-to-moderate COPD.BMJ open respiratory research · 2025Observational
- Review
- Chronic cough associated with COPD exacerbation, pneumonia and death in the general population.ERJ open research · 2024Article
- CT airway remodelling and chronic cough.BMJ open respiratory research · 2023Article
- The clinical characteristics and outcomes of different inhaled therapies in chronic obstructive pulmonary disease patients with frequent cough.Annals of medicine · 2023Article
- Article
- Illness Perceptions and Self-Management among People with Chronic Lung Disease and Healthcare Professionals: A Mixed-Method Study Identifying the Local Context.Healthcare (Basel, Switzerland) · 2022Article
- Chronic Bronchitis Affects Outcomes in Smokers without Chronic Obstructive Pulmonary Disease (COPD).Journal of clinical medicine · 2022Article
- The interrelationship of chronic cough and depression: a prospective population-based study.ERJ open research · 2022Article
- Sinonasal Symptoms in COPD: Burden and Associations with Clinical Markers of Disease.International journal of chronic obstructive pulmonary disease · 2022Article
- WAO-ARIA consensus on chronic cough - Part II: Phenotypes and mechanisms of abnormal cough presentation -The World Allergy Organization journal · 2021Review
- Prevalence and incidence of, and risk factors for chronic cough in the adult population: the Rotterdam Study.ERJ open research · 2020Article
- Minimal Clinically Important Differences for Patient-Reported Outcome Measures of Cough and Sputum in Patients with COPD.International journal of chronic obstructive pulmonary disease · 2020Observational
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Authors and funding
9 authors.
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Abstract
Background and purpose: Chronic cough can be a dominant symptom of chronic obstructive pulmonary disease (COPD), although its clinical impact remains unclear. The aim of our study was to identify phenotypic differences according to the presence of chronic cough or sputum and evaluate the impact of chronic cough on the risk of acute exacerbation of COPD (AECOPD). Methods: In a nationwide COPD cohort including 1,613 COPD patients, patients with chronic cough only, those with sputum only, those with chronic bronchitis (CB), and those without cough and sputum were compared with regard to dyspnea, lung function, quality of life (QoL), and risk of AECOPD. Results: The rates of chronic cough, chronic sputum, and both were 23.4%, 32.4%, and 18.2%, respectively. Compared with patients without chronic cough, those with chronic cough exhibited a lower forced expiratory volume in 1 second (% predicted) and diffusing capacity of the lungs for carbon monoxide (% predicted), more frequent AECOPD, more severe dyspnea, and worse QoL. Pulmonary function, dyspnea severity, and QoL worsened in the following order: without cough or sputum, with sputum only, with cough only, and with CB. Multivariate analyses revealed chronic cough as an independent risk factor for a lower lung function, more severe dyspnea, and a poor QoL. Moreover, the risk of future AECOPD was significantly associated with chronic cough (odds ratio 1.56, 95% CI 1.08-2.24), but not with chronic sputum. Conclusion: Our results suggest that chronic cough should be considered as an important phenotype during the determination of high-risk groups of COPD patients.
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