ReviewWorld journal of gastroenterology2018
Irritable bowel syndrome in children: Current knowledge, challenges and opportunities.
Review in World journal of gastroenterology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 52 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Standardized Yoga & Meditation Program for Stress Reduction for Adolescents With Irritable Bowel Syndrome
Adesione Alla Dieta Mediterranea Dei Pazienti Pediatrici Affetti Dalla Sindrome Dell'Intestino Irritabile (IBS): Studio Pilota
Comparative Effect of Trimebutine and Probiotics on Functional Abdominal Pain Disorders (FAPD) in Children: Randomized Clinical Trial (RCT)
Who cites it
52 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Effects of probiotic supplementation on abdominal pain severity in pediatric patients with irritable bowel syndrome: a systematic review and meta-analysis of randomized clinical trials.World journal of pediatrics : WJP · 2022Pooled it
- The Role of Fiber in the Treatment of Functional Gastrointestinal Disorders in Children.Nutrients · 2018Pooled it
- Efficacy and Safety of the Adjuvant Use of Probiotic Bacillus clausii Strains in Pediatric Irritable Bowel Syndrome: A Randomized, Double-Blind, Placebo-Controlled Study.Paediatric drugs · 2023Trial
- Physical Complaints Decrease after Following a Few-Foods Diet in Children with ADHD.Nutrients · 2022Trial
- Illness Uncertainty in Pediatric Irritable Bowel Syndrome: A Pilot Study.Children (Basel, Switzerland) · 2026Article
- Occult constipation masking as irritable bowel syndrome with predominant diarrhea in Bangladeshi children.World journal of gastrointestinal pathophysiology · 2026Article
- Dietary fiber in pediatric gastrointestinal health: a narrative review of evidence and challenges.Clinical and experimental pediatrics · 2026Review
- Clinical characteristics and nutritional profiles of children with different irritable bowel syndrome subtypes: a retrospective hospital-based study.Translational pediatrics · 2026Article
- Article
- Multi-omics mendelian randomization integrating GWAS and eQTL data revealed potential drug target for irritable bowel syndrome.Frontiers in genetics · 2026Article
- Efficacy and Safety of Probiotics in Children with Irritable Bowel Syndrome: A Systematic Review and Meta-Analysis.Microorganisms · 2025Review
- Review
- Self-management and treatment adherence in pediatric irritable bowel syndrome (IBS): A longitudinal study.Journal of psychosomatic research · 2025Article
- Breaking the cycle: Psychological and social dimensions of pediatric functional gastrointestinal disorders.World journal of clinical pediatrics · 2025Article
- Anxiety and Depression in Children with Irritable Bowel Syndrome-A Narrative Review.Diagnostics (Basel, Switzerland) · 2025Review
- Functional Gastrointestinal Disorders and Childhood Obesity: The Role of Diet and Its Impact on Microbiota.Nutrients · 2024Review
- Abdominal Wall-targeted Myofascial Release Therapy in Pediatric Patients with Irritable Bowel Syndrome: A Feasibility and Acceptability Study.International journal of therapeutic massage & bodywork · 2024Article
- Frequency of Irritable Bowel Syndrome Among Children Aged 4 to 9 Years: A Cross-Sectional Study.Clinical pediatrics · 2024Article
- Article
- Nutraceuticals and biotics in pediatric gastrointestinal disorders.European journal of clinical nutrition · 2024Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Irritable bowel syndrome (IBS) is a common and troublesome disorder in children with an increasing prevalence noted during the past two decades. It has a significant effect on the lives of affected children and their families and poses a significant burden on healthcare systems. Standard symptom-based criteria for diagnosis of pediatric IBS have changed several times during the past two decades and there are some differences in interpreting symptoms between different cultures. This has posed a problem when using them to diagnose IBS in clinical practice. A number of potential patho-physiological mechanisms have been described, but so far the exact underlying etiology of IBS is unclear. A few potential therapeutic modalities have been tested in children and only a small number of them have shown some benefit. In addition, most of the described patho-physiological mechanisms and treatment options are based on adult studies. These have surfaced as challenges when dealing with pediatric IBS and they need to be overcome for effective management of children with IBS. Recently suggested top-down and bottom-up models help integrating reported patho-physiological mechanisms and will provide an opportunity for better understanding of the diseases process. Treatment trials targeting single treatment modalities are unlikely to have clinically meaningful therapeutic effects on IBS with multiple integrating patho-physiologies. Trials focusing on multiple combined pharmacological and non-pharmacological therapies are likely to yield more benefit. In addition to treatment, in the future, attention should be paid for possible prevention strategies for IBS.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.