ArticleNature communications2018
Alternative assembly of respiratory complex II connects energy stress to metabolic checkpoints.
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Article in Nature communications, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.
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43citing papers in PubMed
2.5field-weighted citation impact, top 10% of its field
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Who cites it
43 citing papers in PubMed, 74 citations in OpenAlex.
- DRP lyase deficient DNA polymerase beta impairs mitochondrial electron transport chain and compromise mitochondrial DNA integrity.Research square · 2026Article
- Mitochondrial Transfer Rescues Respiration to Support De Novo Pyrimidine Biosynthesis and Tumor Progression.Cancer research · 2026Article
- Targeting the mitochondrial metabolite-dynamics-MDVs-MitoEVs axis: a new frontier in osteoarthritis management.Journal of translational medicine · 2026Review
- CRISPR screen reveals SOX2 as a critical regulator of CD133 and cellular stress response in glioblastoma.Scientific reports · 2025Article
- Complex II assembly drives metabolic adaptation to OXPHOS dysfunction.Science advances · 2025Article
- Similar deficiencies, different outcomes: succinate dehydrogenase loss in adrenal medulla vs. fibroblast cell culture models of paraganglioma.Cancer & metabolism · 2024Article
- Succinate Dehydrogenase and Human Disease: Novel Insights into a Well-Known Enzyme.Biomedicines · 2024Review
- NR4A3 prevents diabetes induced atrial cardiomyopathy by maintaining mitochondrial energy metabolism and reducing oxidative stress.EBioMedicine · 2024Article
- Metabolic Plasticity of Glioblastoma Cells in Response to DHODH Inhibitor BAY2402234 Treatment.Metabolites · 2024Article
- Drp1 controls complex II assembly and skeletal muscle metabolism by Sdhaf2 action on mitochondria.Science advances · 2024Article
- Disordered-to-ordered transitions in assembly factors allow the complex II catalytic subunit to switch binding partners.Nature communications · 2024Article
- Reduced Protein Import via TIM23 SORT Drives Disease Pathology in TIMM50-Associated Mitochondrial Disease.Molecular and cellular biology · 2024Article
- The mitochondrial succinate dehydrogenase complex controls the STAT3-IL-10 pathway in inflammatory macrophages.iScience · 2023Article
- Complex II Biology in Aging, Health, and Disease.Antioxidants (Basel, Switzerland) · 2023Review
- An evolving view of complex II-noncanonical complexes, megacomplexes, respiration, signaling, and beyond.The Journal of biological chemistry · 2023Review
- Liver saturated fat content associates with hepatic DNA methylation in obese individuals.Clinical epigenetics · 2023Article
- Cardiolipin coordinates inflammatory metabolic reprogramming through regulation of Complex II disassembly and degradation.Science advances · 2023Article
- Mitochondrial supercomplex assembly regulates metabolic features and glutamine dependency in mammalian cells.Theranostics · 2023Article
- Unraveling the functional consequences of a novel germline missense mutation (R38C) in the yeast model of succinate dehydrogenase subunit B: insights into neurodegenerative disorders.Frontiers in molecular neuroscience · 2023Article
- Succinate dehydrogenase variants in paraganglioma: why are B subunit variants 'bad'?Endocrine oncology (Bristol, England) · 2023Article
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Authors and funding
27 authors at 8 institutions in 8 countries.
Ayenachew Bezawork-GeletaSchool of Medical Sciences, Griffith University, Southport, 4222, Qld, Australia. a.bezawork-geleta@griffith.edu.au.
He WenDepartment of Biochemistry and Molecular Biology, Shenzhen University School of Medicine, Shenzhen, 518060, China.
LanFeng DongSchool of Medical Sciences, Griffith University, Southport, 4222, Qld, Australia.
Bing YanSchool of Medical Sciences, Griffith University, Southport, 4222, Qld, Australia.
Jelena ViderSchool of Medical Sciences, Griffith University, Southport, 4222, Qld, Australia.ORCID http://orcid.org/0000-0003-1696-9812
Stepana BoukalovaInstitute of Biotechnology, Czech Academy of Sciences, Prague-West, 25250, Czech Republic.
Linda KrobovaInstitute of Biotechnology, Czech Academy of Sciences, Prague-West, 25250, Czech Republic.
Katerina VanovaInstitute of Biotechnology, Czech Academy of Sciences, Prague-West, 25250, Czech Republic.
Renata ZobalovaInstitute of Biotechnology, Czech Academy of Sciences, Prague-West, 25250, Czech Republic.
Margarita SobolInstitute of Molecular Genetics, Czech Academy of Sciences, Prague, 14220, Czech Republic.
Pavel HozakInstitute of Molecular Genetics, Czech Academy of Sciences, Prague, 14220, Czech Republic.
Silvia Magalhaes NovaisInstitute of Biotechnology, Czech Academy of Sciences, Prague-West, 25250, Czech Republic.
Veronika CaisovaEunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, 20892, MD, USA.
Pavel AbaffyInstitute of Biotechnology, Czech Academy of Sciences, Prague-West, 25250, Czech Republic.
Ravindra NaraineInstitute of Biotechnology, Czech Academy of Sciences, Prague-West, 25250, Czech Republic.
Ying PangEunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, 20892, MD, USA.
Thiri ZawAustralian Proteome Analysis Facility, Macquarie University, North Ryde, 2109, NSW, Australia.
Ping ZhangSchool of Medical Sciences, Griffith University, Southport, 4222, Qld, Australia.
Radek SindelkaInstitute of Biotechnology, Czech Academy of Sciences, Prague-West, 25250, Czech Republic.
Mikael KubistaInstitute of Biotechnology, Czech Academy of Sciences, Prague-West, 25250, Czech Republic.
Steven ZurynClem Jones Centre for Ageing Dementia Research, Queensland Brain Institute, University of Queensland, Brisbane, 4072, Qld, Australia.
Mark P MolloyAustralian Proteome Analysis Facility, Macquarie University, North Ryde, 2109, NSW, Australia.
Michael V BerridgeMalaghan Institute of Medical Research, Wellington, 6242, New Zealand.
Karel PacakEunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, 20892, MD, USA.
Jakub RohlenaInstitute of Biotechnology, Czech Academy of Sciences, Prague-West, 25250, Czech Republic. jakub.rohlena@ibt.cas.cz.
Sunghyouk ParkCollege of Pharmacy, Natural Product Research Institute, Seoul National University, Seoul, 08826, Korea. psh@snu.ac.kr.
Jiri NeuzilSchool of Medical Sciences, Griffith University, Southport, 4222, Qld, Australia. j.neuzil@griffith.edu.au.
Czech Academy of Sciences, Institute of Biotechnology · CZGriffith University · AUCzech Academy of Sciences · CZNational Institutes of Health · USMacquarie University · AUSeoul National University · KRMalaghan Institute of Medical Research · NZThe University of Queensland · AU
Funding
Diagnosis, Pathophysiology And Molecular Biology of Pheochromocytoma and ParagangliomaZIAHD008735 · NICHD · EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT · PI PACAK, KAREL · 2009 to 2024
$28.4MAbstract
Cell growth and survival depend on a delicate balance between energy production and synthesis of metabolites. Here, we provide evidence that an alternative mitochondrial complex II (CII) assembly, designated as CII
Indexed as
Stress, PhysiologicalAnimalsBiosynthetic PathwaysCell Line, TumorElectron Transport Complex IIEnergy MetabolismGene Knockout TechniquesHEK293 CellsHumansMiceMice, Inbred BALB CMice, NudeMitochondriaMutationParagangliomaRNA, Small InterferingElectron Transport Complex IIrespiratory complex IIRNA, Small InterferingSDHA protein, humanSDHB protein, humanSuccinate Dehydrogenase
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.