ArticleCell death & disease2018
Ablation of somatostatin cells leads to impaired pancreatic islet function and neonatal death in rodents.
Article in Cell death & disease, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
25 citing papers in PubMed, 39 citations in OpenAlex.
- The Role of Somatostatin in the Gastrointestinal Tract.Biology · 2025Review
- Scaffold-free endocrine tissue engineering: role of islet organization and implications in type 1 diabetes.BMC endocrine disorders · 2025Review
- Regulated and adaptive in vivo insulin secretion from islets only containing β-cells.Nature metabolism · 2024Article
- Generation and application of novel hES cell reporter lines for the differentiation and maturation of hPS cell-derived islet-like clusters.Scientific reports · 2024Article
- Inhibition of somatostatin enhances the long-term metabolic outcomes of sleeve gastrectomy in mice.Molecular metabolism · 2024Article
- Somatostatin signalling coordinates energy metabolism allocation to reproduction in zebrafish.BMC biology · 2024Article
- Review
- The Importance of Intra-Islet Communication in the Function and Plasticity of the Islets of Langerhans during Health and Diabetes.International journal of molecular sciences · 2024Review
- Paracrine signalling by pancreatic δ cells determines the glycaemic set point in mice.Nature metabolism · 2024Article
- Pancreatic δ Cells: An Overlooked Cell in Focus.Advances in anatomy, embryology, and cell biology · 2024Review
- Novel corticotropin-releasing hormone receptor genes (CRHR1 and CRHR2) linkage to and association with polycystic ovary syndrome.Journal of ovarian research · 2023Article
- Sex differences in islet stress responses support female β cell resilience.Molecular metabolism · 2023Article
- Somatostatin Containing δ-Cell Number Is Reduced in Type-2 Diabetes.International journal of molecular sciences · 2023Article
- Somatostatin receptors in congenital hyperinsulinism: Biology to bedside.Frontiers in endocrinology · 2022Review
- Article
- Pancreatic Ppy-expressing γ-cells display mixed phenotypic traits and the adaptive plasticity to engage insulin production.Nature communications · 2021Article
- Review
- δ-Cells: The Neighborhood Watch in the Islet Community.Biology · 2021Review
- Differential Morphological Diagnosis of Various Forms of Congenital Hyperinsulinism in Children.Frontiers in endocrinology · 2021Article
- Paracrine signaling in islet function and survival.Journal of molecular medicine (Berlin, Germany) · 2020Review
Corrections and comments
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Authors and funding
11 authors at 2 institutions in 2 countries.
Funding
Abstract
The somatostatin (SST)-secreting cells were mainly distributed in the pancreatic islets, brain, stomach and intestine in mammals and have many physiological functions. In particular, the SST-secreting δ cell is the third most common cell type in the islets of Langerhans. Recent studies have suggested that dysregulation of paracrine interaction between the pancreatic δ cells and β cells results in impaired glucose homeostasis and contributes to diabetes development. However, direct evidence of the functional importance of SST cells in glucose homeostasis control is still lacking. In the present study, we specifically ablated SST-secreting cells by crossing Sst-cre transgenic mice with R26
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.