ArticleNature communications2018
Parasitic insect-derived miRNAs modulate host development.
Article in Nature communications, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 55 papers.
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Who cites it
55 citing papers in PubMed, 97 citations in OpenAlex.
- Transforming hosts into nurseries and nutrients: strategic manipulation by endoparasitoid wasps.Journal of advanced research · 2026Review
- Systematic profiling of nudivirus-like genes reveals conserved and differentiated roles in a domesticated endogenous virus.PLoS pathogens · 2026Article
- Geographic genetic divergence and ecological viral communities shape the virome of Chilo suppressalis.Microbiome · 2026Article
- Dual interference with host neuropeptide signaling allows parasitoid wasp to hijack host sugar metabolism.The EMBO journal · 2026Article
- A Set of Novel Venom Proteins Enables Parasitoid Wasps to Exploit Older Hosts and Coexist with Competitors.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Transcriptional Control of Lipid Metabolism.Advances in experimental medicine and biology · 2026Review
- Building the parasitic waspFrontiers in insect science · 2026Article
- Transcriptomic Analysis ofInsects · 2025Article
- Extracellular Vesicles in Arthropods: Biogenesis, Functions, Isolation Methods and Applications.Journal of extracellular vesicles · 2025Review
- Effects of Parasitism and Venom from the EndoparasitoidInsects · 2025Article
- A symbiotic gene stimulates aggressive behavior favoring the survival of parasitized caterpillars.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Symbiotic bracovirus of a parasite modulate host ecdysis process.Cellular and molecular life sciences : CMLS · 2025Article
- miRNA Expression Response ofInsects · 2025Article
- Interactions of juvenile hormone, 20-hydroxyecdysone, developmental genes, and miRNAs during pupal development in Apis mellifera.Scientific reports · 2025Article
- Innate Immunity in Insects: The Lights and Shadows of Phenoloxidase System Activation.International journal of molecular sciences · 2025Review
- Parasitoid wasp venoms degradeScience advances · 2025Article
- Isolation of extracellular vesicles from insect hemolymph.Current research in insect science · 2025Review
- Coordinated molecular and ecological adaptations underlie a highly successful parasitoid.eLife · 2024Article
- Elucidating the ecophysiology of soybean pod-sucking stinkbug Riptortus pedestris (Hemiptera: Alydidae) based on de novo genome assembly and transcriptome analysis.BMC genomics · 2024Article
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Authors and funding
22 authors at 6 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Parasitic wasps produce several factors including venom, polydnaviruses (PDVs) and specialized wasp cells named teratocytes that benefit the survival of offspring by altering the physiology of hosts. However, the underlying molecular mechanisms for the alterations remain unclear. Here we find that the teratocytes of Cotesia vestalis, an endoparasitoid of the diamondback moth Plutella xylostella, and its associated bracovirus (CvBV) can produce miRNAs and deliver the products into the host via different ways. Certain miRNAs in the parasitized host are mainly produced by teratocytes, while the expression level of miRNAs encoded by CvBV can be 100-fold greater in parasitized hosts than non-parasitized ones. We further show that one teratocyte-produced miRNA (Cve-miR-281-3p) and one CvBV-produced miRNA (Cve-miR-novel22-5p-1) arrest host growth by modulating expression of the host ecdysone receptor (EcR). Altogether, our results show the first evidence of cross-species regulation by miRNAs in animal parasitism and their possible function in the alteration of host physiology during parasitism.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.