Evidence map›Paper›PMID 29880830›Full record

ArticleCell death & disease2018

Histamine deficiency aggravates cardiac injury through miR-206/216b-Atg13 axis-mediated autophagic-dependant apoptosis.

Suling Ding, Mieradilijiang Abudupataer, Zheliang Zhou, Jinmiao Chen, Hui Li, Lili Xu, Weiwei Zhang, Shuning Zhang, Yunzeng Zou, Tao Hong and 3 more

Open access · goldAbstract read
In one paragraph

Article in Cell death & disease, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed
2.4field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 38 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Histamine in Diabetic Cardiovascular Complications.Reviews in cardiovascular medicine · 2026
    Review
  5. Article
  6. Article
  7. Review
  8. Article
  9. Article
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  11. Review
  12. Article
  13. Acta pharmaceutica Sinica. B · 2022
    Article
  14. Article
  15. Article
  16. Article
  17. Review
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 5 institutions in 2 countries.

Suling DingShanghai Institute of Cardiovascular Diseases, Zhongshan Hospital, Institutes of Biomedical Sciences, Fudan University, Shanghai, 200032, China.
Mieradilijiang AbudupataerDepartment of Cardiac Surgery, Zhongshan Hospital, Fudan University, Shanghai, 200032, China.
Zheliang ZhouDepartment of Cardiac Surgery, Zhongshan Hospital, Fudan University, Shanghai, 200032, China.
Jinmiao ChenDepartment of Cardiac Surgery, Zhongshan Hospital, Fudan University, Shanghai, 200032, China.
Hui LiShanghai Institute of Cardiovascular Diseases, Zhongshan Hospital, Institutes of Biomedical Sciences, Fudan University, Shanghai, 200032, China.
Lili XuDepartment of Cardiology, Zhongshan Hospital, Fudan University, Shanghai, 200032, China.
Weiwei ZhangShanghai Institute of Cardiovascular Diseases, Zhongshan Hospital, Institutes of Biomedical Sciences, Fudan University, Shanghai, 200032, China.
Shuning ZhangDepartment of Cardiology, Zhongshan Hospital, Fudan University, Shanghai, 200032, China.
Yunzeng ZouShanghai Institute of Cardiovascular Diseases, Zhongshan Hospital, Institutes of Biomedical Sciences, Fudan University, Shanghai, 200032, China.
Tao HongDepartment of Cardiac Surgery, Zhongshan Hospital, Fudan University, Shanghai, 200032, China.
Timothy C WangDepartment of Medicine and Irving Cancer Research Center, Columbia University, New York, NY, 10032, USA.
Xiangdong YangShanghai Institute of Cardiovascular Diseases, Zhongshan Hospital, Institutes of Biomedical Sciences, Fudan University, Shanghai, 200032, China. yang.xiangdong@zs-hospital.sh.cn.
Junbo GeShanghai Institute of Cardiovascular Diseases, Zhongshan Hospital, Institutes of Biomedical Sciences, Fudan University, Shanghai, 200032, China. jbge@zs-hospital.sh.cn.
Sun Yat-sen University · CNFudan University · CNThe First Affiliated Hospital, Sun Yat-sen University · CNCancer Research Center · USZhongshan Hospital · CN

Funding

National Natural Science Foundation of China (National Science Foundation of China) 81370402National Natural Science Foundation of China (National Science Foundation of China) 81500262National Natural Science Foundation of China (National Science Foundation of China) 81521001National Natural Science Foundation of China (National Science Foundation of China) 91439121
6 · The paper itself

Abstract

Histamine is a widely distributed biogenic amine involved in the regulation of an array of biological processes. Serum histamine level is markedly elevated in the early stages of acute myocardial infarction, whereas the role it plays remains unclear. Histidine decarboxylase (HDC) is the unique enzyme responsible for histamine production, and cardiac injury is significantly aggravated in HDC knockout mice (HDC

Indexed as

ApoptosisAutophagyAnimalsApoptosis Regulatory ProteinsBase SequenceCaspase 8Cell HypoxiaCell LineEnzyme ActivationFas-Associated Death Domain ProteinHistamineHumansMiceMicroRNAsModels, BiologicalMyocardial InfarctionApoptosis Regulatory ProteinsATG13 protein, mouseCaspase 8Fadd protein, mouseFas-Associated Death Domain ProteinHistamineMicroRNAsMirn206 microRNA, mouseMIRN216 microRNA, mouseReceptors, Histamine

Identifiers

PMID29880830
PMCPMC5992227
OpenAlexW2806475234

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.