Evidence map›Paper›PMID 29880757›Full record

ArticleViruses2018

Comparison of Porcine Airway and Intestinal Epithelial Cell Lines for the Susceptibility and Expression of Pattern Recognition Receptors upon Influenza Virus Infection.

Milton Thomas, Max Pierson, Tirth Uprety, Laihua Zhu, Zhiguang Ran, Chithra C Sreenivasan, Dan Wang, Ben Hause, David H Francis, Feng Li and 1 more

Open access · goldAbstract readComparative Study
In one paragraph

Article in Viruses, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
2.3field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 19 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Milton ThomasDepartment of Biology and Microbiology, South Dakota State University, Brookings, SD 57007, USA. miltontn@gmail.com.
Max PiersonDepartment of Biology and Microbiology, South Dakota State University, Brookings, SD 57007, USA. max.pierson@cardinalhealth.com.
Tirth UpretyDepartment of Biology and Microbiology, South Dakota State University, Brookings, SD 57007, USA. Tirth.Uprety@sdstate.edu.
Laihua ZhuDepartment of Biology and Microbiology, South Dakota State University, Brookings, SD 57007, USA. laihuazhu@yahoo.com.
Zhiguang RanDepartment of Biology and Microbiology, South Dakota State University, Brookings, SD 57007, USA. zhgran@sina.com.
Chithra C SreenivasanDepartment of Biology and Microbiology, South Dakota State University, Brookings, SD 57007, USA. Chithra.Sreenivasan@sdstate.edu.
Dan WangDepartment of Biology and Microbiology, South Dakota State University, Brookings, SD 57007, USA. Dan.Wang@sdstate.edu.
Ben HauseCambridge Technologies, Oxford Street Worthington, MN 56187, USA. bhause@cambridgetechnologies.com.
David H FrancisDepartment of Veterinary and Biomedical Sciences, South Dakota State University, Brookings, SD 57007, USA. David.Francis@sdstate.edu.
Feng LiDepartment of Biology and Microbiology, South Dakota State University, Brookings, SD 57007, USA. Feng.Li@sdstate.edu.
Radhey S KaushikDepartment of Biology and Microbiology, South Dakota State University, Brookings, SD 57007, USA. Radhey.Kaushik@sdstate.edu.ORCID 0000-0003-4204-9323
South Dakota State University · USBrookings Institution · US

Funding

Stimulation of broadly neutralizing antibodies against influenza in a pig modelR15AI089690 · NIAID · SOUTH DAKOTA STATE UNIVERSITY · PI FRANCIS, DAVID HULET, KAUSHIK, RADHEY SHYAM · 2011 to 2011
$424k
Study of Novel Influenza C VirusR21AI107379 · NIAID · SOUTH DAKOTA STATE UNIVERSITY · PI LI, FENG · 2014 to 2015
$394k
NIAID NIH HHS R15 AI089690NIAID NIH HHS R21 AI107379
6 · The paper itself

Abstract

Influenza viruses infect the epithelial cells of the swine respiratory tract. Cell lines derived from the respiratory tract of pigs could serve as an excellent in vitro model for studying the pathogenesis of influenza viruses. In this study, we examined the replication of influenza viruses in the MK1-OSU cell line, which was clonally derived from pig airway epithelium. MK1-OSU cells expressed both cytokeratin and vimentin proteins and displayed several sugar moieties on the cell membrane. These cells also expressed both Sial2-3Gal and Sial2-6Gal receptors and were susceptible to swine influenza A, but not to human B and C viruses. Interestingly, these cells were also permissive to infection by influenza D virus that utilized 9-

Indexed as

AnimalsCell LineEpithelial CellsIntestinal MucosaOrthomyxoviridaeReceptors, Pattern RecognitionRespiratory MucosaSwineReceptors, Pattern Recognitioninfluenzainnate immunityMK1-OSUrespiratory epithelial cellsRIG-I-like receptorSD-PJECTLR

Identifiers

PMID29880757
PMCPMC6024858
OpenAlexW2805127374

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.