Evidence map›Paper›PMID 29880640›Full record

ArticleThe Journal of biological chemistry2018

Structural insight into the human mitochondrial tRNA purine N1-methyltransferase and ribonuclease P complexes.

Stephanie Oerum, Martine Roovers, Robert P Rambo, Jola Kopec, Henry J Bailey, Fiona Fitzpatrick, Joseph A Newman, William G Newman, Albert Amberger, Johannes Zschocke and 3 more

Open access · hybridAbstract read
In one paragraph

Article in The Journal of biological chemistry, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
1.4field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 39 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Review
  5. The Secret Life of NJournal of molecular biology · 2025
    Review
  6. Review
  7. The role of m5C, m1A and m7G modifications in tumors of urinary system.Frontiers in cell and developmental biology · 2025
    Review
  8. Article
  9. Article
  10. Review
  11. Article
  12. Journal of Cancer · 2024
    Article
  13. Review
  14. RNA modifications in cancer.British journal of cancer · 2023
    Review
  15. Review
  16. Review
  17. Article
  18. The Dynamic Network of RNP RNase P Subunits.International journal of molecular sciences · 2021
    Review
  19. Structural basis of RNA processing by human mitochondrial RNase P.Nature structural & molecular biology · 2021
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 5 institutions in 3 countries.

Stephanie OerumStructural Genomics Consortium, Nuffield Department of Clinical Medicine, University of Oxford, Oxford OX3 7BN, United Kingdom.
Martine RooversInstitut de Recherches Labiris, B-1070 Anderlecht, Belgium.
Robert P RamboDiamond Light Source, Harwell Science and Innovation Center, Didcot OX11 0QG, United Kingdom.
Jola KopecStructural Genomics Consortium, Nuffield Department of Clinical Medicine, University of Oxford, Oxford OX3 7BN, United Kingdom.
Henry J BaileyStructural Genomics Consortium, Nuffield Department of Clinical Medicine, University of Oxford, Oxford OX3 7BN, United Kingdom.
Fiona FitzpatrickStructural Genomics Consortium, Nuffield Department of Clinical Medicine, University of Oxford, Oxford OX3 7BN, United Kingdom.
Joseph A NewmanStructural Genomics Consortium, Nuffield Department of Clinical Medicine, University of Oxford, Oxford OX3 7BN, United Kingdom.
William G NewmanManchester Centre for Genomic Medicine, Manchester University NHS Foundation Trust, University of Manchester, Manchester, M13 9WL, United Kingdom.
Albert AmbergerDivision of Human Genetics, Medical University of Innsbruck, Innsbruck 6020, Austria.
Johannes ZschockeDivision of Human Genetics, Medical University of Innsbruck, Innsbruck 6020, Austria.
Louis DroogmansLaboratoire de Microbiologie, Universite libre de Bruxelles, 1050 Belgium.
Udo OppermannStructural Genomics Consortium, Nuffield Department of Clinical Medicine, University of Oxford, Oxford OX3 7BN, United Kingdom; Botnar Research Centre, NIHR Oxford Biomedical Research Unit, Oxford OX3 7LD, United Kingdom. Electronic address: udo.oppermann@sgc.ox.ac.uk.
Wyatt W YueStructural Genomics Consortium, Nuffield Department of Clinical Medicine, University of Oxford, Oxford OX3 7BN, United Kingdom. Electronic address: wyatt.yue@sgc.ox.ac.uk.
University of Oxford · GBInnsbruck Medical University · ATDiamond Light Source · GBManchester University NHS Foundation Trust · GBUniversité Libre de Bruxelles · BE

Funding

Wellcome TrustWellcome Trust 092809/Z/10/Z
6 · The paper itself

Abstract

Mitochondrial tRNAs are transcribed as long polycistronic transcripts of precursor tRNAs and undergo posttranscriptional modifications such as endonucleolytic processing and methylation required for their correct structure and function. Among them, 5'-end processing and purine 9 N1-methylation of mitochondrial tRNA are catalyzed by two proteinaceous complexes with overlapping subunit composition. The Mg

Indexed as

Models, Molecular3-Hydroxyacyl CoA DehydrogenasesCrystallography, X-RayHumansMethyltransferasesMultienzyme ComplexesRibonuclease PRNA, MitochondrialRNA, TransferScattering, Small Angle3-Hydroxyacyl CoA DehydrogenasesHSD17B10 protein, humanMethyltransferasesMultienzyme ComplexesPRORP protein, humanRibonuclease PRNA, MitochondrialRNA, TransferTRMT10c protein, humancomplexHSD10HSD17B10MRPPPRORPribonuclease P (RNase P)RNA methylationRNA methyltransferasetransfer RNA (tRNA)TRMT10C

Identifiers

PMID29880640
PMCPMC6102140
OpenAlexW2805591138

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.