Evidence map›Paper›PMID 29880601›Full record

ArticleThe EMBO journal2018

Diminished nuclear RNA decay upon

Katsutoshi Imamura, Akiko Takaya, Yo-Ichi Ishida, Yayoi Fukuoka, Toshiki Taya, Ryo Nakaki, Miho Kakeda, Naoto Imamachi, Aiko Sato, Toshimichi Yamada and 10 more

Open access · goldAbstract read
In one paragraph

Article in The EMBO journal, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.

0numbers the graph read from it
0cells of the map it votes in
38citing papers in PubMed
3.3field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

38 citing papers in PubMed, 68 citations in OpenAlex.

  1. Article
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  3. Long non-coding RNA transcripts inNon-coding RNA research · 2025
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  7. Article
  8. Review
  9. Unveiling the Hidden Regulators: The Impact of lncRNAs on Zoonoses.International journal of molecular sciences · 2024
    Review
  10. The early macrophage response to pathogens requires dynamic regulation of the nuclear paraspeckle.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  11. Review
  12. Article
  13. Review
  14. Review
  15. Article
  16. Article
  17. Review
  18. Article
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  20. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

20 authors at 6 institutions in 2 countries.

Katsutoshi ImamuraDepartment of Microbiology and Molecular Genetics, Graduate School of Pharmaceutical Sciences, Chiba University, Chiba, Japan.
Akiko TakayaDepartment of Microbiology and Molecular Genetics, Graduate School of Pharmaceutical Sciences, Chiba University, Chiba, Japan.
Yo-Ichi IshidaLaboratory of Molecular and Cellular Biochemistry, Meiji Pharmaceutical University, Tokyo, Japan.
Yayoi FukuokaAgilent Technologies Japan, Ltd., Tokyo, Japan.
Toshiki TayaAgilent Technologies Japan, Ltd., Tokyo, Japan.
Ryo NakakiRhelixa, Inc., Tokyo, Japan.
Miho KakedaIsotope Science Center, The University of Tokyo, Tokyo, Japan.
Naoto ImamachiIsotope Science Center, The University of Tokyo, Tokyo, Japan.
Aiko SatoIsotope Science Center, The University of Tokyo, Tokyo, Japan.
Toshimichi YamadaLaboratory of Molecular and Cellular Biochemistry, Meiji Pharmaceutical University, Tokyo, Japan.
Rena Onoguchi-MizutaniIsotope Science Center, The University of Tokyo, Tokyo, Japan.
Gen AkizukiIsotope Science Center, The University of Tokyo, Tokyo, Japan.
Tanzina TanuIsotope Science Center, The University of Tokyo, Tokyo, Japan.
Kazuyuki TaoIsotope Science Center, The University of Tokyo, Tokyo, Japan.
Sotaro MiyaoLaboratory of Molecular and Cellular Biochemistry, Meiji Pharmaceutical University, Tokyo, Japan.
Yutaka SuzukiDepartment of Medical Genome Sciences, Graduate School of Frontier Sciences, The University of Tokyo, Chiba, Japan.
Masami NagahamaLaboratory of Molecular and Cellular Biochemistry, Meiji Pharmaceutical University, Tokyo, Japan.
Tomoko YamamotoMedical Mycology Research Center, Chiba University, Chiba, Japan.
Torben Heick JensenDepartment of Molecular Biology and Genetics, Aarhus University, Aarhus C, Denmark.
Nobuyoshi AkimitsuIsotope Science Center, The University of Tokyo, Tokyo, Japan akimitsu@ric.u-tokyo.ac.jp.ORCID 0000-0002-3190-2942
The University of Tokyo · JPMeiji Pharmaceutical University · JPAgilent Technologies (Japan) · JPChiba University · JPAarhus University · DKChiba University Hospital · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cytoplasmic mRNA degradation controls gene expression to help eliminate pathogens during infection. However, it has remained unclear whether such regulation also extends to nuclear RNA decay. Here, we show that 145 unstable nuclear RNAs, including enhancer RNAs (eRNAs) and long noncoding RNAs (lncRNAs) such as NEAT1v2, are stabilized upon

Indexed as

RNA, NuclearRNA, UntranslatedCell SurvivalHeLa CellsHumansSalmonella entericaSalmonella InfectionsUp-RegulationRNA, NuclearRNA, Untranslatedinnate immune responselncRNAnuclear exosomenuclear RNA degradationSalmonella infection

Identifiers

PMID29880601
PMCPMC6028032
OpenAlexW2806143126

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.