Evidence map›Paper›PMID 29880529›Full record

ArticleCirculation. Arrhythmia and electrophysiology2018

Role of 3-Dimensional Architecture of Scar and Surviving Tissue in Ventricular Tachycardia: Insights From High-Resolution Ex Vivo Porcine Models.

Farhad Pashakhanloo, Daniel A Herzka, Henry Halperin, Elliot R McVeigh, Natalia A Trayanova

Open access · bronzeAbstract readVideo-Audio Media
PubMed Full text at PMC Publisher
In one paragraph

Article in Circulation. Arrhythmia and electrophysiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed
3.6field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 43 citations in OpenAlex.

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  12. [Simulators and simulator training in interventional electrophysiology].Herzschrittmachertherapie & Elektrophysiologie · 2022
    Article
  13. Atrial fibrillation driver identification through regional mutual information networks: a modeling perspective.Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing · 2022
    Article
  14. Article
  15. An early multicenter experience of the novel high-density star-shaped mapping catheter in complex arrhythmias.Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Farhad PashakhanlooDepartment of Biomedical Engineering (F.P., D.A.H., E.R.M., N.A.T.).
Daniel A HerzkaDepartment of Biomedical Engineering (F.P., D.A.H., E.R.M., N.A.T.).
Henry HalperinDepartment of Medicine (H.H.).
Elliot R McVeighDepartment of Biomedical Engineering (F.P., D.A.H., E.R.M., N.A.T.).
Natalia A TrayanovaDepartment of Biomedical Engineering (F.P., D.A.H., E.R.M., N.A.T.) ntrayanova@jhu.edu.
United States Nuclear Regulatory Commission · US

Funding

Virtual Electrophysiology LaboratoryDP1HL123271 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI TRAYANOVA, NATALIA A. · 2013 to 2017
$4.0M
Exploration of Arrhythmogenic Triggers and Substrates in Heart FailureR01HL126802 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI EFIMOV, IGOR R, GORELIK, JULIA · 2016 to 2019
$2.8M
NHLBI NIH HHS DP1 HL123271NHLBI NIH HHS R01 HL126802
6 · The paper itself

Abstract

backgroundAn improved knowledge of the spatial organization of infarct structure and its contribution to ventricular tachycardia (VT) is important for designing optimal treatments. This study explores the relationship between the 3-dimensional structure of the healed infarct and the VT reentrant pathways in high-resolution models of infarcted porcine hearts.

methodsStructurally detailed models of infarcted ventricles were reconstructed from ex vivo late gadolinium enhancement and diffusion tensor magnetic resonance imaging data of 8 chronically infarcted porcine hearts at submillimeter resolution (0.25×0.25×0.5 mm

resultsThe scar-mapped thickness metric revealed the heterogeneous organization of infarct and enabled us to systematically characterize the distribution of surviving tissue thickness in 8 hearts. Simulation results demonstrated the involvement of a subendocardial tissue layer of varying thickness in the majority of VT pathways. Importantly, they revealed that VT pathways are most frequently established within thin surviving tissue structures of thickness ≤2.2 mm (90th percentile) surrounding the scar.

conclusionsThe combination of high-resolution imaging data and ventricular simulations revealed the 3-dimensional distribution of surviving tissue surrounding the scar and demonstrated its involvement in VT pathways. The new knowledge obtained in this study contributes toward a better understanding of infarct-related VT.

Indexed as

Action PotentialsAnimalsCicatrixComputer SimulationDiffusion Magnetic Resonance ImagingDisease Models, AnimalHeart RateHeart VentriclesImage Interpretation, Computer-AssistedModels, CardiovascularMyocardial InfarctionMyocardiumSus scrofaTachycardia, VentricularTissue Survivalarrhythmias, cardiaccomputer simulationmagnetic resonance imagingmyocardial infarctiontachycardia, ventricular

Identifiers

PMID29880529
PMCPMC5994925
OpenAlexW2805296335

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.