Evidence map›Paper›PMID 29880507›Full record

ArticleJournal of nuclear medicine : official publication, Society of Nuclear Medicine2019

Abnormal Ventilation-Perfusion Scan Is Associated with Pulmonary Hypertension in Sickle Cell Adults.

Alem Mehari, Norris Igbineweka, Darlene Allen, Jim Nichols, Swee Lay Thein, Nargues A Weir

Open access · bronzeAbstract read
In one paragraph

Article in Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
1.3field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it, 22 citations in OpenAlex.

  1. Pooled it
  2. Ventilation-perfusion (V/Q) scans: trends from medicare part B (2013-2023).The international journal of cardiovascular imaging · 2026
    Article
  3. Article
  4. Review
  5. Article
  6. Article
  7. Review
  8. Cardiac pathophysiology in sickle cell disease.Journal of thrombosis and thrombolysis · 2021
    Review
  9. Optimal disease management and health monitoring in adults with sickle cell disease.Hematology. American Society of Hematology. Education Program · 2019
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Alem MehariSickle Cell Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland alem.mehari@howard.edu.
Norris IgbinewekaSickle Cell Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland.
Darlene AllenSickle Cell Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland.
Jim NicholsSickle Cell Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland.
Swee Lay TheinSickle Cell Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland.
Nargues A WeirSickle Cell Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland.
National Institutes of Health · USHoward University · USNational Heart Lung and Blood Institute · US

Funding

Studies of the Natural History of Sickle Cell DiseaseZIAHL006233 · NHLBI · NATIONAL HEART, LUNG, AND BLOOD INSTITUTE · PI THEIN, SWEE LAY · 2017 to 2025
$10.9M
Intramural NIH HHS Z99 HL999999
6 · The paper itself

Abstract

Pulmonary hypertension (PH) in adults with sickle cell disease (SCD) is associated with early mortality. Chronic thromboembolic PH (CTEPH) is an important complication and contributor to PH in SCD but is likely underappreciated. Guidelines recommend ventilation-perfusion (V/Q) scintigraphy as the imaging modality of choice to exclude CTEPH. Data on V/Q scanning are limited in SCD. Our objective was to compare the performance of V/Q scanning with that of CT pulmonary angiography (CTPA) and to report clinical outcomes associated with abnormal V/Q findings.

Indexed as

Ventilation-Perfusion ScanAdultAnemia, Sickle CellFemaleHumansHypertension, PulmonaryMaleRetrospective StudiesCTEPHmortalitysickle cell diseaseventilation–perfusion scintigraphy

Identifiers

PMID29880507
PMCPMC6910625
OpenAlexW2806147267

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.