Regulating the regulator: Bhlhe40 directly keeps IL-10 in check.

Open access · bronzeAbstract readComment

In one paragraph

Article in The Journal of experimental medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it

0cells of the map it votes in

6citing papers in PubMed

0.8field-weighted citation impact, top 30% of its field

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 9 citations in OpenAlex.

BHLHE40 as a transcriptional rheostat: decoding microenvironmental signals in context-dependent tumor plasticity.Science China. Life sciences · 2026
Review
IL-10-Producing ILCs: Molecular Mechanisms and Disease Relevance.Frontiers in immunology · 2021
Review
BHLHE40 Regulates IL-10 and IFN-Frontiers in immunology · 2021
Article
Transcription Factor Bhlhe40 in Immunity and Autoimmunity.Trends in immunology · 2020
Review
Molecular switches for regulating the differentiation of inflammatory and IL-10-producing anti-inflammatory T-helper cells.Cellular and molecular life sciences : CMLS · 2020
Review
Bhlhe40 mediates tissue-specific control of macrophage proliferation in homeostasis and type 2 immunity.Nature immunology · 2019
Article

4 · The record

Corrections and comments

Comment on
The transcription factor Bhlhe40 is a switch of inflammatory versus antiinflammatory Th1 cell fate determination.2018
Comment on
Bhlhe40 is an essential repressor of IL-10 during2018

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Leona GabryšováLaboratory of Immunoregulation and Infection, The Francis Crick Institute, London, England, UK.ORCID 0000-0003-3529-1306

Anne O'GarraLaboratory of Immunoregulation and Infection, The Francis Crick Institute, London, England, UK MH-jmc@crick.ac.uk.ORCID 0000-0001-9845-6134

The Francis Crick Institute · GB

Funding

Medical Research Council MC_U117565642

6 · The paper itself

Abstract

In this issue of

Indexed as

Mycobacterium tuberculosisTuberculosisHumansInterleukin-10Interleukin-10

Identifiers

PMID29880485

DOI10.1084/jem.20180824

PMCPMC6028514

OpenAlexW2807215352

What OpenQuestion holds

Textmetadata

LicenceCC BY-NC-SA

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.