ArticleAJNR. American journal of neuroradiology2018
Thalamocortical Connections and Executive Function in Pediatric Temporal and Frontal Lobe Epilepsy.
Article in AJNR. American journal of neuroradiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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15 citing papers in PubMed, 29 citations in OpenAlex.
- Gamma suppression correlates with thalamic stimulation therapeutic response in intractable epilepsy.Epilepsia · 2026Article
- Thalamocortical connectivity and nucleus-specific thalamic dysfunction in temporal lobe epilepsy: an integrative review.Brain structure & function · 2026Review
- Diffusion Tractography Biomarker for Epilepsy Severity in Children With Drug-Resistant Epilepsy.Annals of clinical and translational neurology · 2026Article
- Abnormalities of thalamus and thalamocortical pathways in patients with refractory epilepsy caused by focal cortical dysplasia - MRI study.Epilepsia open · 2025Article
- Clinical implications of sagittal stratum damage: Laterality, neuroanatomical developmental considerations, and functional outcomes.Surgical neurology international · 2025Review
- Structural and functional brain changes in X-linked Charcot-Marie-Tooth disease: insights from a multimodal neuroimaging study.Neuroradiology · 2022Article
- Disrupted hypothalamic functional connectivity related to cognitive impairment after diffuse axonal injury.Medicine · 2021Observational
- Structural and functional motor-network disruptions predict selective action-concept deficits: Evidence from frontal lobe epilepsy.Cortex; a journal devoted to the study of the nervous system and behavior · 2021Article
- Multimodal neurocognitive markers of frontal lobe epilepsy: Insights from ecological text processing.NeuroImage · 2021Article
- Characterization of Hippocampal-Thalamic-Cortical Morphometric Reorganization in Temporal Lobe Epilepsy.Frontiers in neurology · 2021Article
- The Critical Modulatory Role of Spiny Stellate Cells in Seizure Onset Based on Dynamic Analysis of a Neural Mass Model.Frontiers in neuroscience · 2021Article
- Thalamocortical Functional Connectivity in Patients With White Matter Hyperintensities.Frontiers in aging neuroscience · 2021Article
- Altered White Matter Structural Network in Frontal and Temporal Lobe Epilepsy: A Graph-Theoretical Study.Frontiers in neurology · 2020Article
- Altered intrinsic brain activity associated with outcome in frontal lobe epilepsy.Scientific reports · 2019Article
- The Conjoint Analysis of Microstructural and Morphological Changes of Gray Matter During Aging.Frontiers in neurology · 2019Article
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Authors and funding
3 authors at 2 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
background and purposeLargely accepted in the literature is the role the interconnections between the thalamus and cortex play in generalized epilepsy. However, thalamocortical involvement is less understood in focal epilepsy in terms of the effect of seizures on thalamocortical circuitry in the developing brain and subsequent cognitive outcome. We investigated thalamocortical pathway microstructure in pediatric frontal lobe epilepsy and temporal lobe epilepsy and examined the associations between pathway microstructure and measures of executive function. MATERIALS AND
methodsWe examined thalamocortical connections in 24 children with frontal lobe epilepsy, 17 patients with temporal lobe epilepsy, and 25 healthy children using DTI. We investigated several executive function measures in patients and controls, which were distilled into latent executive function components to compare among groups, and the associations between measures of thalamocortical microstructure and executive function.
resultsWe found no differences in thalamocortical pathway microstructure between the groups, but aspects of executive function (mental flexibility/inhibition/shifting) were impaired in the frontal lobe epilepsy group compared with controls. In patients with frontal lobe epilepsy, younger age at seizure onset and a greater number of antiepileptic drugs were associated with DTI indices indicative of damaged/less developed thalamocortical pathways. In patients with temporal lobe epilepsy, poorer performance on all measures of executive function was associated with DTI indices reflective of damaged/less developed pathways.
conclusionsOur results give insight into vulnerable neural networks in pediatric focal epilepsy and suggest thalamocortical pathway damage as a potential mechanism of executive function impairment in temporal lobe epilepsy but not frontal lobe epilepsy. Identifying structure-function relations can help inform how we measure functional and cognitive/behavioral outcomes in these populations.
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