ArticleEpidemiology and infection2018
Severe morbidity among hospitalised adults with acute influenza and other respiratory infections: 2014-2015 and 2015-2016.
Article in Epidemiology and infection, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 23 citations in OpenAlex.
- Neuraminidase Inhibitors and Hospital Length of Stay: A Meta-analysis of Individual Participant Data to Determine Treatment Effectiveness Among Patients Hospitalized With Nonfatal 2009 Pandemic Influenza A(H1N1) Virus Infection.The Journal of infectious diseases · 2020Pooled it
- Risk factors for re-hospitalization within 90 days of discharge for severe influenza in children.BMC infectious diseases · 2025Article
- A vicious cycle of frailty and acute lower respiratory infection among community-dwelling adults (≥ 60 years): Findings from a multi-site INSPIRE cohort study, India.PLOS global public health · 2024Article
- K-medoids clustering of hospital admission characteristics to classify severity of influenza virus infection.Influenza and other respiratory viruses · 2023Article
- Re-Admission of COVID-19 Patients Hospitalized with Omicron Variant-A Retrospective Cohort Study.Journal of clinical medicine · 2022Article
- Comorbid conditions as risk factors for West Nile neuroinvasive disease in Ontario, Canada: a population-based cohort study.Epidemiology and infection · 2022Article
- Distinct influenza surveillance networks and their agreement in recording regional influenza circulation: Experience from Southeast Michigan.Influenza and other respiratory viruses · 2022Article
- Outcomes among critically ill adults with influenza infection.Journal of the Association of Medical Microbiology and Infectious Disease Canada = Journal officiel de l'Association pour la microbiologie medicale et l'infectiologie Canada · 2021Article
- Risk-factors for re-admission and outcome of patients hospitalized with confirmed COVID-19.Scientific reports · 2021Article
- Influenza Vaccine Effectiveness in Inpatient and Outpatient Settings in the United States, 2015-2018.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2021Article
- Clinical outcomes and characteristics of patients hospitalized for Influenza or COVID-19 in Germany.International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases · 2021Observational
- Antibody and Cell-Mediated Immune Responses Are Correlates of Protection against Influenza Infection in Vaccinated Older Adults.Vaccines · 2021Article
- Article
- Frailty Hinders Recovery From Influenza and Acute Respiratory Illness in Older Adults.The Journal of infectious diseases · 2020Article
- Influenza Vaccine Effectiveness in the Inpatient Setting: Evaluation of Potential Bias in the Test-Negative Design by Use of Alternate Control Groups.American journal of epidemiology · 2020Article
- Article
- Virological Surveillance of Influenza in the eight epidemic seasons after the 2009 pandemic in Emilia-Romagna (Northern Italy).Acta bio-medica : Atenei Parmensis · 2019Article
Corrections and comments
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Authors and funding
10 authors at 3 institutions in 1 country.
Funding
Abstract
Our objective was to identify predictors of severe acute respiratory infection in hospitalised patients and understand the impact of vaccination and neuraminidase inhibitor administration on severe influenza. We analysed data from a study evaluating influenza vaccine effectiveness in two Michigan hospitals during the 2014-2015 and 2015-2016 influenza seasons. Adults admitted to the hospital with an acute respiratory infection were eligible. Through patient interview and medical record review, we evaluated potential risk factors for severe disease, defined as ICU admission, 30-day readmission, and hospital length of stay (LOS). Two hundred sixteen of 1119 participants had PCR-confirmed influenza. Frailty score, Charlson score and tertile of prior-year healthcare visits were associated with LOS. Charlson score >2 (OR 1.5 (1.0-2.3)) was associated with ICU admission. Highest tertile of prior-year visits (OR 0.3 (0.2-0.7)) was associated with decreased ICU admission. Increasing tertile of visits (OR 1.5 (1.2-1.8)) was associated with 30-day readmission. Frailty and prior-year healthcare visits were associated with 30-day readmission among influenza-positive participants. Neuraminidase inhibitors were associated with decreased LOS among vaccinated participants with influenza A (HR 1.6 (1.0-2.4)). Overall, frailty and lack of prior-year healthcare visits were predictors of disease severity. Neuraminidase inhibitors were associated with reduced severity among vaccine recipients.
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Registered trials
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