ArticleJournal of orthopaedic surgery and research2018
Effects of obesity on the healing of bone fracture in mice.
Article in Journal of orthopaedic surgery and research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 53 citations in OpenAlex.
- Obesity prolongs the pro-inflammatory response and attenuates bone healing on titanium implants.Acta biomaterialia · 2025Article
- Personalized bone organoid using iPSC-derived cells for clinically relevant applications.Research square · 2024Article
- Research Progress in Calcitonin Gene-Related Peptide and Bone Repair.Biomolecules · 2023Review
- Relationships between Obesity and Incidence of Fractures in a Middle-Aged Population: A Study from the CARTaGENE Cohort.JBMR plus · 2023Article
- The role of PIEZO ion channels in the musculoskeletal system.American journal of physiology. Cell physiology · 2023Review
- The role of non-steroidal anti-inflammatory drugs as adjuncts to periodontal treatment and in periodontal regeneration.Journal of translational medicine · 2023Review
- Gait Analysis to Monitor Fracture Healing of the Lower Leg.Bioengineering (Basel, Switzerland) · 2023Review
- Precedence of Bone Loss Accompanied with Changes in Body Composition and Body Fat Distribution in Patients with Type 2 Diabetes Mellitus.Journal of diabetes research · 2023Article
- Does obesity affect diaphyseal femoral fracture healing treated with intramedullary locking nail?Joint diseases and related surgery · 2023Article
- Individual Concepts in Foot Surgery: A Comparison of Xenogeneic and Autologous Bone Grafts Used in Adults for Lateral Calcaneus-Lengthening Osteotomy According to Evans.Journal of personalized medicine · 2022Article
- In Vivo Application of Silica-Derived Inks for Bone Tissue Engineering: A 10-Year Systematic Review.Bioengineering (Basel, Switzerland) · 2022Review
- Adipose tissue in bone regeneration - stem cell source and beyond.World journal of stem cells · 2022Review
- The Effect of Obesity on Pediatric Tibia Fractures.The Iowa orthopaedic journal · 2022Article
- Fracture Related Infections and Their Risk Factors for Treatment Failure-A Major Trauma Centre Perspective.Diagnostics (Basel, Switzerland) · 2022Article
- Methodology, selection, and integration of fracture healing assessments in mice.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2021Review
- Resolution of inflammation in bone regeneration: From understandings to therapeutic applications.Biomaterials · 2021Review
- Bone Healing and Inflammation: Principles of Fracture and Repair.Seminars in plastic surgery · 2021Review
- Adiponectin signalling in bone homeostasis, with age and in disease.Bone research · 2021Review
- Regeneration during Obesity: An Impaired Homeostasis.Animals : an open access journal from MDPI · 2020Article
- The Effects of Calcitonin Gene-Related Peptide on Bone Homeostasis and Regeneration.Current osteoporosis reports · 2020Review
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundObesity affects bone health to varying degrees, depending on the skeletal site (weight-bearing or non-weight-bearing) and compartment (cortical or trabecular), and is a risk factor for orthopedic disorders, including bone fractures. However, the effect and mechanisms of obesity on healing of bone fracture is little understood.
methodsThe healing bone fractures of the tibia in genetically obese mice was evaluated relative to normal mice at weekly intervals for 28 days using X-ray scans, hematoxylin and eosin (H&E) stain, and alcian blue (AB) stain. Plasma concentrations of relevant proteins were also compared via enzyme-linked immunosorbent assay (ELISA). These included calcitonin gene-related peptide (CGRP), fibroblast growth factor (FGF), transforming growth factor beta 1 (TGF-β1), and tumor necrosis factor-α (TNF-α).
resultsBone fracture healing was delayed in the obese mice compared with the control group of normal mice, based on X-ray, H&E stain, and AB stain analysis. This was accompanied with significantly low plasma CGRP, FGF, and TGF-β1 (ELISA). However, TNF-α was significantly higher in obese mice compared with the control.
conclusionBone fracture healing was significantly slower in the obese mice, relative to that of normal mice. The lower levels of CGRP, FGF, and TGF-β, and higher level of TNF-α, observed in obese mice may contribute to this observed delay in fracture healing.
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