Evidence map›Paper›PMID 29879989›Full record

ArticleJournal of translational medicine2018

Protein markers of dysfunctional HDL in scavenger receptor class B type I deficient mice.

Jia Cao, Yanyong Xu, Feifei Li, Liang Shang, Daping Fan, Hong Yu

Open access · goldAbstract read
In one paragraph

Article in Journal of translational medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.0field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 18 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Review
  6. Review
  7. Review
  8. HDL and Scavenger Receptor Class B Type I (SRBI).Advances in experimental medicine and biology · 2022
    Review
  9. Article
  10. Article
  11. Role of serum amyloid A in atherosclerosis.Current opinion in lipidology · 2019
    Review
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Jia CaoDepartment of Biochemistry and Molecular Biology, Hubei Provincial Key Laboratory of Developmentally Originated Disease, Wuhan University School of Basic Medical Sciences, 185 Donghu Road, Bldg. 2, 2-206, Wuhan, 430071, China.
Yanyong XuDepartment of Biochemistry and Molecular Biology, Hubei Provincial Key Laboratory of Developmentally Originated Disease, Wuhan University School of Basic Medical Sciences, 185 Donghu Road, Bldg. 2, 2-206, Wuhan, 430071, China.
Feifei LiDepartment of Biochemistry and Molecular Biology, Hubei Provincial Key Laboratory of Developmentally Originated Disease, Wuhan University School of Basic Medical Sciences, 185 Donghu Road, Bldg. 2, 2-206, Wuhan, 430071, China.
Liang ShangDepartment of Biochemistry and Molecular Biology, Hubei Provincial Key Laboratory of Developmentally Originated Disease, Wuhan University School of Basic Medical Sciences, 185 Donghu Road, Bldg. 2, 2-206, Wuhan, 430071, China.
Daping FanDepartment of Cell Biology and Anatomy, School of Medicine, University of South Carolina, Columbia, SC, USA.
Hong YuDepartment of Biochemistry and Molecular Biology, Hubei Provincial Key Laboratory of Developmentally Originated Disease, Wuhan University School of Basic Medical Sciences, 185 Donghu Road, Bldg. 2, 2-206, Wuhan, 430071, China. yu.hong@whu.edu.cn.ORCID 0000-0002-8397-7081
Wuhan University · CNUniversity of South Carolina · US

Funding

Sparstolonin B as an anti-atherogenic agentR01HL116626 · NHLBI · UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA · PI FAN, DAPING · 2013 to 2017
$1.7M
National Natural Science Foundation of China 30770850National Natural Science Foundation of China 81201335National Natural Science Foundation of China 81670423NHLBI NIH HHS R01 HL116626NIH HHS HL116626
6 · The paper itself

Abstract

backgroundScavenger receptor class B type I (SR-BI) plays a key role in high density lipoproteins (HDL) metabolism. SR-BI deficiency in mice results in enhanced susceptibility to atherosclerosis with abnormal large, cholesterol enriched, and functional impaired HDL. This study was to characterize the protein markers of dysfunctional HDL in SR-BI deficient (SR-BI

methodsShotgun proteomics and 2-D gel electrophoresis were performed to examine the profile of HDL protein and distribution of HDL particles isolated from SR-BI

resultsThe relative amount of protein in SR-BI

conclusionSR-BI deficiency leading to dysfunctional HDL is closely related to alteration of HDL protein, suggesting that identification of apoAI, PON1, SAA, apoAIV, and A1AT may serve as the valuable protein markers for diagnosis and therapeutics of dysfunctional HDL-related metabolic diseases.

Indexed as

AnimalsAnti-Inflammatory AgentsAntioxidantsBiomarkersCholesterolFemaleHumansLipoproteins, HDLMaleMice, Inbred C57BLMice, KnockoutProbucolProteomicsScavenger Receptors, Class BAnti-Inflammatory AgentsAntioxidantsBiomarkersCholesterolLipoproteins, HDLProbucolScarb1 protein, mouseScavenger Receptors, Class BDysfunctionHigh density lipoproteinProbucolProtein markersSR-BI

Identifiers

PMID29879989
PMCPMC5992774
OpenAlexW2806508033

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.