Evidence map›Paper›PMID 29879865›Full record

ArticleRNA biology2018

Recoding of the selenocysteine UGA codon by cysteine in the presence of a non-canonical tRNA

Oscar Vargas-Rodriguez, Markus Englert, Anna Merkuryev, Takahito Mukai, Dieter Söll

Open access · bronzeAbstract read
In one paragraph

Article in RNA biology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.6field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 14 citations in OpenAlex.

  1. Frontiers in microbiology · 2026
    Article
  2. Article
  3. Article
  4. Article
  5. Bioinformatic Prediction of an tRNAInternational journal of molecular sciences · 2021
    Article
  6. Article
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Oscar Vargas-Rodrigueza Department of Molecular Biophysics and Biochemistry , Yale University , New Haven , CT , USA.ORCID 0000-0002-2301-2800
Markus Englerta Department of Molecular Biophysics and Biochemistry , Yale University , New Haven , CT , USA.
Anna Merkuryevb Department of Chemistry , Yale University , New Haven , CT , USA.
Takahito Mukaia Department of Molecular Biophysics and Biochemistry , Yale University , New Haven , CT , USA.
Dieter Sölla Department of Molecular Biophysics and Biochemistry , Yale University , New Haven , CT , USA.ORCID 0000-0002-3077-8986
Yale University · US

Funding

TRANSFER RNAR01GM022854 · NIGMS · YALE UNIVERSITY · PI SOLL, DIETER · 1985 to 2016
$21.3M
Studies of Transfer RNAR35GM122560 · NIGMS · YALE UNIVERSITY · PI SOLL, DIETER · 2017 to 2022
$5.6M
NIGMS NIH HHS R01 GM022854NIGMS NIH HHS R35 GM122560
6 · The paper itself

Abstract

In many organisms, the UGA stop codon is recoded to insert selenocysteine (Sec) into proteins. Sec incorporation in bacteria is directed by an mRNA element, known as the Sec-insertion sequence (SECIS), located downstream of the Sec codon. Unlike other aminoacyl-tRNAs, Sec-tRNA

Indexed as

Amino Acyl-tRNA SynthetasesAnticodonBacterial ProteinsCodon, TerminatorCysteineDesulfotomaculumEscherichia coliGenetic CodeModels, MolecularMutationNucleic Acid ConformationPeptide Elongation Factor TuPeptococcaceaeProtein BiosynthesisRibosomesRNA, Transfer, CysAmino Acyl-tRNA SynthetasesAnticodonBacterial ProteinsCodon, TerminatorCysteinecysteinyl-tRNA synthetasePeptide Elongation Factor TuRNA, Transfer, CysSelB protein, BacteriaSelenocysteineSelenoproteinsbioinformaticsGenetic coderecodingselenocysteinetRNA

Identifiers

PMID29879865
PMCPMC6103700
OpenAlexW2806867751

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.